A STRUCTURE BASED DRUG DESIGN STUDY ON VEGFR-2 INHIBITORS

Language: English

Published by LAP LAMBERT Academic Publishing Apr 2011, 2011

3844319891 / 9783844319897

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Softcover

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This item is printed on demand - it takes 3-4 days longer - Neuware -VEGF (Vascular Endothelial Growth Factor) is a potent angiogenic signal implicated with a key role in several pathological processes, including tumour vascularization, angiogenesis, and endothelial cell growth. The members of VEGF family bind to tyrosine kinase receptors on the cell surface to initiate a signalling cascade. VEGFR-2 is one such Receptor Tyrosine Kinase(RTK) that is found to mediate a majority of the cellular responses to VEGF. A structure based drug design study was performed on VEGFR-2 inhibitors based on the article Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors 1 and 2 . The target protein was retrieved from the Protein Data Bank (I.D. 2OH4), based on the Ramachandran plot. The structures of reported inhibitors were obtained in 3-D format using standard software packages. These 3-D analogues were docked to the protein of choice using Molegro Virtual Docker. Based on a correlation between experimentally obtained log IC50 values and the results of the docking study, direct drug design was carried out. Novel inhibitors with significantly higher moldock scores were obtained with simple modifications to the original structure. 72 pp. Englisch.…

Seller Inventory # 9783844319897

Title
A STRUCTURE BASED DRUG DESIGN STUDY ON VEGFR-2 INHIBITORS
Author
Ajay Babu P
Publisher
LAP LAMBERT Academic Publishing Apr 2011
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3844319891
ISBN 13
9783844319897
Item weight
125 grams
Dimensions
220x150x5 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

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BuchWeltWeit Ludwig Meier e.K.

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