STATISTICAL METHODS FOR SURVIVAL TRIAL DESIGN: WITH APPLICATIONS TO CANCER CLINICAL TRIALS USING R - JIANRONG WU
Language: English
Published by Taylor & Francis Group, 2018
- Hardcover
- New
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- Title
- STATISTICAL METHODS FOR SURVIVAL TRIAL DESIGN: WITH APPLICATIONS TO CANCER CLINICAL TRIALS USING R - JIANRONG WU
- Author
- Wu, Jianrong
- Publisher
- Taylor & Francis Group
- Publication year
- 2018
- Condition
- New
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 1138033227
- ISBN 13
- 9781138033221
- Series
- Book 90 of 155: Chapman & Hall/CRC Biostatistics
Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials.
This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.
"Synopsis" may belong to another edition of this title.
About the Author
Jianrong (John) Wu is a professor in the Division of Cancer Biostatistics, Department of Biostatistics, Markey Cancer Center, University of Kentucky. He has more than 15 years’ experience of designing and conducting cancer clinical trials at St. Jude Children’s Research Hospital and has developed several novel statistical methods for designing phase II and phase III survival trials.
"About the title" may belong to another edition of this title.
Biblios
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