Ryanodine Receptors : Structure, Function and Dysfunction in Clinical Disease
Language: English
Published by Springer, 2014
Series: Book 110 of 253 - Developments in Cardiovascular Medicine
- Softcover
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- Title
- Ryanodine Receptors : Structure, Function and Dysfunction in Clinical Disease
- Author
- Wehrens, Xander H. T. (EDT); Marks, Andrew R. (EDT)
- Publisher
- Springer
- Publication year
- 2014
- Condition
- As New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 1461498406
- ISBN 13
- 9781461498407
- Series
- Book 110 of 253: Developments in Cardiovascular Medicine
Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions.
David E. Clapham, MD, PhD
Professor of Neurobiology and Pediatrics
Harvard Medical School
"Synopsis" may belong to another edition of this title.
From the Back Cover
In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor.
"In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology."
David E. Clapham, MD, PhD
Professor of Neurobiology and Pediatrics
Harvard Medical School
Dr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University.
Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias.
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