Role of the Transcriptome in Breast Cancer Prevention
Language: English
Published by Springer US, 2012
- Hardcover
- New
Condition: New
£ 117.62
Quantity: Over 20 available
Add to basketItem description from seller
Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides new insight on cancer prevention based on meticulously researched processed that have been gleaned from basic to translational research with a direct clinical application Targeted to the medical profession and those interested in biomedic.
Seller Inventory # 4198570
- Title
- Role of the Transcriptome in Breast Cancer Prevention
- Author
- Jose Russo|Irma H. Russo
- Publisher
- Springer US
- Publication year
- 2012
- Condition
- New
- Binding
- Gebunden
- Language
- English
- ISBN 10
- 1461448832
- ISBN 13
- 9781461448839
"Synopsis" may belong to another edition of this title.
From the Back Cover
This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
"About the title" may belong to another edition of this title.
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| Item | 16 to 45 business days | 16 to 45 business days |
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