Role of TREK background potassium channels in nociception (Paperback)

Language: English

Published by Our Knowledge Publishing, 2026

6630199987 / 9786630199987

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Paperback. Potassium channels with two pore domains (K2p) generate background K+ currents, which play a major role in membrane depolarization and cellular excitability. They are implicated in anesthesia, neuroprotection, depression, and pain. The K2p channel subfamily-TREK-1, TREK-2, and TRAAK-is modulated by pH, lipids (including polyunsaturated fatty acids), membrane stretching, and temperature. TREK-1 and TREK-2 are inactivated by phosphorylation of the G protein-coupled receptor (GPCR) via PKA and PKC. The analgesic effects of morphine are mediated by various signaling pathways downstream of m-opioid receptors, and TREK channels contribute to morphine-induced analgesia in mice. Here, we investigated the response of the dorsal root ganglion (DRG) in wild-type and triple-KO TREK-1-/- -TREK-2-/--TRAAK-/- mice to the application of morphine and capsaicin using calcium imaging. We also characterized an anti-TREK-2 antibody to study TREK-2 expression in DRG neurons. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Title
Role of TREK background potassium channels in nociception (Paperback)
Author
Rachid Akki
Publisher
Our Knowledge Publishing
Publication year
2026
Condition
new
Binding
Paperback
Language
English
ISBN 10
6630199987
ISBN 13
9786630199987

Grand Eagle Retail

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