Role of Proteases in Cellular Dysfunction
Language: English
Published by Springer New York, 2016
Series: Book 4 of 25 - Advances in Biochemistry in Health and Disease
- Softcover
- New
Condition: New
£ 119.18
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Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. First volume to comprehensively explore the role of proteases in various diseasesProvides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug de.
Seller Inventory # 447955919
- Title
- Role of Proteases in Cellular Dysfunction
- Author
- Dhalla, Naranjan S.|Chakraborti, Sajal
- Publisher
- Springer New York
- Publication year
- 2016
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 149394634X
- ISBN 13
- 9781493946341
- Series
- Book 4 of 25: Advances in Biochemistry in Health and Disease
It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues.
Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
"Synopsis" may belong to another edition of this title.
About the Author
Sajal Chakraborti is a professor at the University of Kalyani, India.
Naranjan S. Dhalla is a professor at St. Boniface General Hospital and the University of Manitoba, Canada.
"About the title" may belong to another edition of this title.
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