Role of Matrix Metalloproteinases in Tissue Remodeling : relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research

Language: English

Published by VDM Verlag Dr. Müller, 2009

3639207890 / 9783639207897

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Softcover

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nach der Bestellung gedruckt Neuware - Printed after ordering - Matrix metalloproteinases (MMP) are the key enzymes in the pathogenesis of osteoarthritis and inflammatory arthritis. This study was performed on the rat common carotid artery model. This model has better accessibility and reliable injury assessment techniques in comparison to articular cartilage. This groundbreaking study shows that MMP inhibition resulted in a significant decrease in the cell proliferation and the remodeling of the extracellular matrix up to 2 months after the MMP injection versus untreated control group and that these effects were associated with a marked reduction in MMP-2 activity. We strongly advocate testing of non hydroxamate type matrix metalloproteinase inhibitors in larger animals and in the clinical setting for degenerative joint and disc disease. Dr. Margolin's 'out of the box' thinking, original study design and sharp indepth analysis are a new important step in restenosis, aortic aneurism and metastasis research as well in developing a disease modifying agent for degenerative disc and joint disease.…

Seller Inventory # 9783639207897

Title
Role of Matrix Metalloproteinases in Tissue Remodeling : relevance to pathogenesis of restenosis, aortic aneurism, joint and disc degeneration research
Author
Leon Margolin
Publisher
VDM Verlag Dr. Müller
Publication year
2009
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3639207890
ISBN 13
9783639207897
Item weight
147 grams
Dimensions
22.00x15.00x0.50 cm

AHA-BUCH GmbH

Einbeck, Germany

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