Role of the Choroid Plexus in Health and Disease

Jeppe Praetorius

ISBN 10: 1071605380 / ISBN 13: 9781071605387

Published by Springer US Apr 2021, 2021

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to thebrain tissue.Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier.Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers' understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences. 296 pp. Englisch.

Seller Inventory # 9781071605387

Bibliographic Details

• Title: Role of the Choroid Plexus in Health and Disease
• Publisher: Springer US Apr 2021
• Publication Date: 2021
• Language: English
• ISBN 10: 1071605380
• ISBN 13: 9781071605387
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 17D millimeters 235 millimeters width by 155 millimeters height by 17 millimeters depth
• Weight: 452 grams

About this title

Synopsis

Broadens understanding of the clinical importance of the choroid plexus as the main source of cerebrospinal fluid 

gives insights into Drug-development strategies targeting the blood cerebrospinal fluid barrier using the choroid plexus epithelial cells

Emphazises the coorrelation between production and composition of CSF and the maintance of normal brain function   

About the Author

Jeppe Praetorius

Department of Biomedicine

Aarhus University

Aarhus

Denmark

Bonnie Blazer-Yost

Department of Biology

Indiana University – Purdue University Indianapolis

Indianapolis

Indiana

USA

Helle Damkier

Department of Biomedicine

Aarhus University

Aarhus

Denmark