Reversible Phosphorylation and Oocyte Maturation : Regulation of Germinal Vesicle Breakdown and Chromatin Remodeling
Language: English
Published by VDM Verlag Dr. Müller Mär 2008, 2008
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 83.89
Quantity: 2 available
Add to basketItem description from seller
Neuware - The delicate nature of reproduction is evidenced by the fact that the female gamete is notorious for having high rates of chromosomal abnormalities. It is estimated10-25% of all human conceptions are chromosomally abnormal due to an error in chromosome segregation during meiosis. Furthermore, studies indicate greater than 95% of this human aneuploidy is attributable to defects within the meiotic machinery of the oocyte, rather than that of the sperm. This results in chromosomal non-disjunction leading to embryonic aneuploidy, miscarriage, infertility and congenital defects. Nevertheless, causative factors and intraoocyte biochemical signaling pathways causing these chromosomal perturbations are unknown. Therefore, elucidating regulatory mechanisms involved in oocyte meiosis is imperative to fully understand this complex process and establish potential therapies to circumvent oocyte derived embryonic aneuploidies. This dissertation will review the origin, as well as development and growth of the oocyte. Furthermore, major mechanistic and cellular events occurring during oocyte meiosis critical to ensure proper development and cellular ploidy will be discussed, focusing on the role of reversible phosphorylation in control of these processes.…
Seller Inventory # 9783836462860
- Title
- Reversible Phosphorylation and Oocyte Maturation : Regulation of Germinal Vesicle Breakdown and Chromatin Remodeling
- Author
- Jason Swain
- Publisher
- VDM Verlag Dr. Müller Mär 2008
- Publication year
- 2008
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3836462869
- ISBN 13
- 9783836462860
- Item weight
- 335 grams
- Dimensions
- 24.00x0.00x0.00 cm
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