Regulatory Networks of Gene Expression in Heart and Skeletal Muscle Cells : The Role of Histone Modifications and Transcription Factors in Muscle Cell Development and Maintenance

Language: English

Published by VDM Verlag Dr. Müller, VDM Verlag Dr. Müller E.K., 2008

3836483734 / 9783836483735

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nach der Bestellung gedruckt Neuware - Printed after ordering - The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression. In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modifications and their potential interactions with key cardiac transcription factors in the context of muscle development and congenital heart diseases are presented. Several hundred genes regulated by the transcription factors Gata4, Mef2a, Nkx2.5, and Srf were identified, demonstrating their essential role in the formation of cardiac structures. The findings support the existence of a complex combinatorial 'histone code' and suggest that histone modifications have further functions as signaling marks. This book is addressed to researchers in a modern molecular biology laboratory, including the fields of biology, biochemistry, bioinformatics, and medicine.; The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression.In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modifications and their potential interactions with key cardiac transcription factors in the context of muscle development and congenital heart diseases are presented. Several hundred genes regulated by the transcription factors Gata4, Mef2a, Nkx2.5, and Srf were identified, demonstrating their essential role in the formation of cardiac structures. The findings support the existence of a complex combinatorial 'histone code' and suggest that histone modifications have further functions as signaling marks.This book is addressed to researchers in a modern molecular biology laboratory, including the fields of biology, biochemistry, bioinformatics, and medicine.…

Title
Regulatory Networks of Gene Expression in Heart and Skeletal Muscle Cells : The Role of Histone Modifications and Transcription Factors in Muscle Cell Development and Maintenance
Author
Jenny J. Fischer
Publisher
VDM Verlag Dr. Müller, VDM Verlag Dr. Müller E.K.
Publication year
2008
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3836483734
ISBN 13
9783836483735
Item weight
272 grams
Dimensions
220x150x10 mm

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