Regulation of the cell cycle phosphatase CDC25C in acute leukemia

Language: English

Published by Omniscriptum, Our Knowledge Publishing, 2025

6208902770 / 9786208902773

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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Softcover

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This item is printed on demand - it takes 3-4 days longer - Neuware -Internal tandem duplications in the FLT3 receptor gene (FLT3-ITD) are found in approximately 30% of patients with acute myeloid leukemia (AML). This oncogene influences various functions of the AML cell and leads to uncontrolled proliferation. Clinically, FLT3-ITD is associated with a poor prognosis in patients with AML. In this study, the influence of FLT3-ITD on the phosphatase CDC25C, which as a cell cycle regulator significantly influences the control of cell division, was investigated. The experiments described here showed that CDC25C is phosphorylated by FLT3-ITD and activated in an uncontrolled manner. In the leukemia cell model, a primarily protective effect of CDC25C was shown in the presence of oncogenic stress. The genetically non-intact cells were increasingly prevented from dividing by CDC25C. However, the simultaneous presence of the FLT3-ITD mutation resulted in a loss of this protective function. The significance of the mechanism described here therefore lies in the control of the response of the leukemia cell to damage within the DNA. However, CDC25C does not have an oncogenic function in the classical sense. 64 pp. Englisch.…

Seller Inventory # 9786208902773

Title
Regulation of the cell cycle phosphatase CDC25C in acute leukemia
Author
Florian Perner
Publisher
Omniscriptum, Our Knowledge Publishing
Publication year
2025
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6208902770
ISBN 13
9786208902773
Item weight
113 grams
Dimensions
220x150x33 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany

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