Recent Progress in the Genetic Epidemiology of Cancer
Language: English
Published by Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 1991, 1991
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 91.84
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -The discipline of genetic epidemiology pertains to the vertical transmission of the susceptibility (predisposition) to a complex disease in a structured population. This statement meets halfway 1 the broad definitiongiven by N. E. Morton and S. c. Chung in 1978 2 and the concise one given by M. -C. King et al. in 1984. 1t pinpoints the fundamental genetic hypothesis, namely, the existence of an inherited condition that predisposes an individual to a specific disease, and the corresponding subject ofinvestigation, the family. Thus, the genetic epidemiological situation consists of three basic elements: (l) the genealogical structure, (2) the mode of inherit ance (i. e. , the 'genetic model') for the trait of interest, and (3) the observable phenotypes of susceptibility. It is clear that genetic epidemiology is a research field posi tioned at the intersection of molecular genetics, population gen etics, and clinical genetics. Perhaps the genealogical tree should be its central element: it evidences something forgotten in mole cular genetics, namely the relationships, and associations with probabilistic and statistical concepts from population genetics. It offers a structure and a 'history' for those clinicians studying familial diseases who are searching for genetic determinants of susceptibility. The genetic epidemiologist begins his analysis with a point on this genealogical tree, namely the proband, and attempts to carry out (nonrandom) 'ascertainment sampling' by using a strategy that depends on the form and dimension (extended pedigrees versus nuclear families) of the tree. 180 pp. Englisch.…
Seller Inventory # 9783540530220
- Title
- Recent Progress in the Genetic Epidemiology of Cancer
- Author
- Petre Tautu
- Publisher
- Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 1991
- Publication year
- 1991
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3540530223
- ISBN 13
- 9783540530220
- Item weight
- 283 grams
- Dimensions
- 235x155x11 mm
"Synopsis" may belong to another edition of this title.
Product Description
"About the title" may belong to another edition of this title.
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
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BuchWeltWeit Ludwig Meier e.K.
Germany
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