Reaktive Sauerstoffspezies ROS basierte Therapeutika : Die Rolle von ROS bei Therapien und Arzneimittelresistenz bei Krebs und Bakterien
Language: German
Published by Verlag Unser Wissen, 2024
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 31.29
Quantity: 1 available
Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - ROS ein 'zweischneidiges Schwert': Die Umgehung der hartnäckigen Arzneimittelresistenz bei Krebs und Bakterien ist für die Wiederherstellung der Gesundheit des Menschen von entscheidender Bedeutung und gibt den Anstoß für Interventionsstrategien. Eine besondere Eigenschaft des Krebsphänotyps ist ein erhöhter Glukosestoffwechsel und oxidativer Stress. Reaktive Sauerstoffspezies (ROS) sind metabolische Nebenprodukte der aeroben Atmung und für die Aufrechterhaltung der Redox-Homöostase in Zellen verantwortlich. Das Redox-Gleichgewicht und der oxidative Stress werden durch antioxidative Enzyme, reduzierte Thiole und NADP(H)-Kofaktoren gesteuert, was für das Überleben und Fortschreiten von Krebszellen entscheidend ist. Auch Escherichia coli (E. coli) und lebensbedrohliche Infektionserreger wie Staphylococcus aureus (SA) und Mycobacterium tuberculosis (Mtb) reagieren sehr empfindlich auf Veränderungen des intrazellulären oxidativen Milieus. Daher könnten kleine Moleküle, die den Gehalt an Antioxidantien modulieren und/oder die intrazelluläre ROS erhöhen, das zelluläre oxidative Milieu stören und den Zelltod auslösen und somit als neuartige Therapeutika dienen. Hier wird eine Reihe von Ansätzen vorgestellt, bei denen die ROS-Modulation in Zellen als Strategie zur Bekämpfung von Krebs und Bakterien eingesetzt wird.…
Seller Inventory # 9786207135547
- Title
- Reaktive Sauerstoffspezies ROS basierte Therapeutika : Die Rolle von ROS bei Therapien und Arzneimittelresistenz bei Krebs und Bakterien
- Author
- Dharmaraja Allimuthu
- Publisher
- Verlag Unser Wissen
- Publication year
- 2024
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- German
- ISBN 10
- 6207135547
- ISBN 13
- 9786207135547
- Item weight
- 125 grams
- Dimensions
- 220x150x5 mm
"Synopsis" may belong to another edition of this title.
Shipping rates from Germany to U.S.A.
| Item | 7 to 10 business days | 5 to 7 business days |
|---|---|---|
| First item | £ 29.62 | £ 38.08 |
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