RP-HPLC Method Development and Validation for Palbociclib and Letrozole
Language: English
Published by LAP LAMBERT Academic Publishing Apr 2020, 2020
- Softcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 47.86
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -Current aim is to develop a simple, rapid, accurate, economic, precise stability indicating assay method for the simultaneous estimation of Palbociclib and Letrozole in pure drug and dosage form. For these purpose choices of a common solvent was essential so various solvent ranges including methanol, ethanol, acetonitrile,and phosphate buffer and various concentrations ranges of various buffers were analyzed. Few methods have been reported on above drugs by using water as common solvent which is the cheapest; therefore finally the common solvent for the above drugs was chosen as sodium Dihydrogen phosphate pH 5.5 (0.05 mm) which is more cheaper than any organic solvent. Palbociclib and Letrozole show maximum absorbance at 220 and 240 nm respectively. Both drugs obey Beer Lambert's law in the concentration range of 2-10 mig/ml and 40-140 mig/ml for Palbociclib and Letrozole respectively.The RP-HPLC method was developed using Intersil ODS-C8, (4.6mm x 250mm; 5mim) column, at ambient temperature using mobile phase Methanol: Acetonitrile: 0.05mM sodium dihydrogen phosphate buffer (pH adjusted to 5.5 with NaOH) in10:10:80 v/v proportion found to give sharp, well defined peaks. 104 pp. Englisch.…
Seller Inventory # 9786202523233
- Title
- RP-HPLC Method Development and Validation for Palbociclib and Letrozole
- Author
- Yuvraj Dange
- Publisher
- LAP LAMBERT Academic Publishing Apr 2020
- Publication year
- 2020
- Condition
- Neu
- Dust jacket
- Dust Jacket Included
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 6202523239
- ISBN 13
- 9786202523233
- Item weight
- 173 grams
- Dimensions
- 220x150x7 mm
"Synopsis" may belong to another edition of this title.
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
Shipping rates from Germany to U.S.A.
| Item | 5 to 15 business days | 5 to 15 business days |
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BuchWeltWeit Ludwig Meier e.K.
Germany
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