RAS: Past, Present, and Future
Language: English
Published by Elsevier Science & Technology, Academic Press, 2022
- Hardcover
- New
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.
AbeBooks seller since January 11, 2012
Condition: New
£ 106.17
Quantity: 2 available
Add to basketItem description from seller
This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once 'undruggable? RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers. Englisch.
Seller Inventory # 9780128244852
- Title
- RAS: Past, Present, and Future
- Author
- John P. O'Bryan
- Publisher
- Elsevier Science & Technology, Academic Press
- Publication year
- 2022
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 0128244852
- ISBN 13
- 9780128244852
- Item weight
- 720 grams
- Dimensions
- 229x152x20 mm
- Overview of the history and development of efforts to pharmacologically inhibit RAS.
- Discussion of the biochemistry and biology of different RAS mutant proteins and how this might be effectively leveraged in the development of anti-RAS therapies.
- Up-to-date reviews of the cutting-edge approaches to develop new anti-RAS pharmacologics.
"Synopsis" may belong to another edition of this title.
About the Author
Dr. Piazza received his Ph.D. from The University of Alabama at Birmingham in 1986 and pursued postdoctoral studies at the Fox Chase Cancer Center and later at Brown University. Dr. Piazza also gained research experience in the pharmaceutical industry with the Proctor and Gamble Company and later with Cell Pathways Inc. Dr. Piazza returned to academic research in 2001 as the Director of Pharmacology at the Institute for Drug Development in San Antonio and later as a Principal Scientist at Southern Research in Birmingham where he established an independent research program funded by the NCI. In 2011, Dr. Piazza joined the University of South Alabama Mitchell Cancer Institute to hold the appointments of Professor of Oncologic Sciences and Pharmacology; Leader, Chemoprevention and Experimental Therapeutics; and Chief of the Drug Discovery Research Center up until 2021. Currently Dr. Piazza serves as the Head of the Department of Drug Discovery and Development and as Director of the Cancer Research Center in the Harrison School of Pharmacy at Auburn University. His research interests are in the field of cancer drug discovery. His research team has discovered and developed several promising drug candidates including a novel class of pan-RAS inhibitors with high potency and selectivity for cancer cells harboring mutant RAS. Dr. Piazza has been continuously funded by the NIH since 2004 and is a co-founder of ADT Pharmaceuticals LLC in Alabama.
"About the title" may belong to another edition of this title.
BuchWeltWeit Ludwig Meier e.K.
Bergisch Gladbach, Germany
AbeBooks seller since January 11, 2012
Shipping rates from Germany to U.S.A.
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BuchWeltWeit Ludwig Meier e.K.
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