Quantifying cell-ECM adhesion by single cell force spectroscopy : Quantifying adhesive interactions between cells and extracellular matrix by atomic force microscopy based single cell force spectroscopy
Language: English
Published by Südwestdeutscher Verlag Für Hochschulschriften, 2011
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 74.55
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nach der Bestellung gedruckt Neuware - Printed after ordering - Integrin-mediated adhesive interactions of cells with the extracellular matrix (ECM) regulate important cellular functions and play a critical role in disease. Therefore, studying the mechanisms underlying integrin-binding and regulation is of great interest. In the presented work three respective biological questions have been addressed using Atomic Force Microscopy based Single Cell Force Spectroscopy (AFM-SCFS). The work is split into six chapters. The first chapter provides an introduction into cell-ECM interactions. Thereafter different adhesion assays are compared and contrasted, and the theoretical Bell-Evans model is discussed. In chapter four, alpha2beta1-integrin mediated cell adhesion to collagen I is quantified. Thereafter the effects of the exposure of cryptic integrin binding sites within collagen I on pre-osteoblasts are analysed. At last, the role of BCR/ABL in modulating myeloid progenitor cell adhesion to stromal cells and ECM-coated substrates is studied. Taken together, the work demonstrates that AFM-SCFS is a versatile tool that permits monitoring of cell adhesion from single-molecule recognition events to the formation of more complex adhesion sites.…
Seller Inventory # 9783838124278
- Title
- Quantifying cell-ECM adhesion by single cell force spectroscopy : Quantifying adhesive interactions between cells and extracellular matrix by atomic force microscopy based single cell force spectroscopy
- Author
- Anna Taubenberger
- Publisher
- Südwestdeutscher Verlag Für Hochschulschriften
- Publication year
- 2011
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3838124278
- ISBN 13
- 9783838124278
- Item weight
- 292 grams
- Dimensions
- 220x150x12 mm
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