Proton Pump Inhibitors

Language: English

Published by Birkhäuser Basel, Birkhäuser Basel Apr 1999, 1999

3764358971 / 9783764358976

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This item is printed on demand - Print on Demand Titel. Neuware -Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists. 268 pp. Englisch.

Seller Inventory # 9783764358976

Title
Proton Pump Inhibitors
Author
Lars Olbe
Publisher
Birkhäuser Basel, Birkhäuser Basel Apr 1999
Publication year
1999
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3764358971
ISBN 13
9783764358976
Item weight
649 grams
Dimensions
250x175x21 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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