Protein Kinase C in Cancer Signaling and Therapy
Language: English
Published by Humana Press Inc., 2012
- Softcover
- New
Seller: Kennys Bookstore, Olney, MD, U.S.A.Kennys Bookstore
AbeBooks seller since October 9, 2009
Condition: New
£ 275.00
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Add to basketItem description from seller
Editor(s): Kazanietz, Marcelo G. Series: Current Cancer Research. Num Pages: 494 pages, 26 black & white illustrations, 11 colour illustrations, 6 black & white tables, biograph. BIC Classification: MJCL; MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 27. Weight in Grams: 771. . 2012. Paperback. . . . . Books ship from the US and Ireland.
Seller Inventory # V9781617796913
- Title
- Protein Kinase C in Cancer Signaling and Therapy
- Author
- . Ed(s): Kazanietz, Marcelo G.
- Publisher
- Humana Press Inc.
- Publication year
- 2012
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 1617796913
- ISBN 13
- 9781617796913
- Series
- Book 2 of 24: Current Cancer Research
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.
This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
"Synopsis" may belong to another edition of this title.
From the Back Cover
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents.
Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. It is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.
Protein Kinase C in Cancer Signaling and Therapy is composed of twenty-three chapters written by leading experts in the field. The book is divided into four sections: Regulation of PKC isozyme function: from genes to biochemistry, PKC isozymes in the control of cell function, PKC isozymes in cancer, and PKC isozymes as targets for cancer therapy. Each section of Protein Kinase C in Cancer Signaling and Therapy begins with an introduction by an established professional in the field of Protein kinase C, followed by chapters that elucidate the importance of PKC in current cancer research.
"About the title" may belong to another edition of this title.
Kennys Bookstore
Olney, MD, U.S.A.
AbeBooks seller since October 9, 2009
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