Prostaglandins And Control Of Vascular Smooth Muscle Cell Proliferation

Schror, K.; Ney, P.

ISBN 10: 3764356898 / ISBN 13: 9783764356897

Published by Birkhauser Verlag, Basel, Boston, Berlin, 1997

About this Item

No dust jacket. Hardcover. Agents and Actions Supplements Vol. 48. Former owner's name is penned on front endpaper. Upper leading corners of boards are dented and rather bent; upper rear leading corner has minor fabric loss. Spine ends are a little creased. Pages are rather sunned around edges. Binding is sound and pages are tight throughout. Contents are clear. AF.

Seller Inventory # 281483

Bibliographic Details

• Title: Prostaglandins And Control Of Vascular Smooth Muscle Cell Proliferation
• Publisher: Birkhauser Verlag, Basel, Boston, Berlin
• Publication Date: 1997
• Language: English
• ISBN 10: 3764356898
• ISBN 13: 9783764356897
• Binding: Hardcover
• Condition: Good
• Dust Jacket Condition: No Dust Jacket
• Book Type: Used

About this title

Synopsis

Uncontrolled proliferation of vascular smooth muscle cells (SMC) in response to vessel injury is a problem with a considerable therapeutic impact. Specifically, restenosis after percutaneous transluminal coronary angioplasty (PTCA) is a clinical problem without any effective drug therapy so far. Thus, there is need for an improved drug therapy but also for an improved understanding of the pathophysiology of growth control in SMC. Cyclooxygenase products, such as prostaglandins and thromboxane, are intimately involved in growth responses. Vasodilatory prostaglandins, such as PGI , PGE or their analogues, have 2 1 been shown to inhibit SMC proliferation. There is also evidence for a markedly increased endogenous prostaglandin production during neointirna formation under the influence of growth factors which includes induction of COX-2. These data suggest that prostaglandins might be considered both targets and tools of growth control. However, there are still many open questions, including the possible interaction of prostaglandins with other growth- modulating factors, in particular NO, the intracellular signal transduction pathways and the role of oxidative stress.

Synopsis

Based on an International Conference held in Vienna, 1996, this volume contains contributions on several aspects of vascular smooth muscle function, phenotype expression and regulation of proliferation of vascular smooth muscle cell by prostaglandis or thromboxane.