Title: Progettazione Sviluppo e caratterizzazione in vitro di compresse di Dofetilide: basate su un sistema di rilascio pulsatile del farmaco (Italian Edition)
Publisher: Edizioni Sapienza
Publication Date: 2024
Language: Italian
ISBN 10: 6208035686
ISBN 13: 9786208035686
Binding: Soft cover
Condition: New

About this title

Synopsis

Lo scopo del libro � quello di sviluppare e caratterizzare un sistema di rilascio pulsatile di un nuovo farmaco, la dofetilide. Inizialmente sono state preparate le compresse di base utilizzando varie concentrazioni di super disintegrati; le compresse di base formulate sono state rivestite con i polimeri utilizzando la tecnologia del rivestimento per compressione. Il sodio amido glicollato, il povidone incrociato e la carmellosa sodica incrociata sono stati i super disintegrati utilizzati nella formulazione delle compresse con nucleo. Tutte le formulazioni di compresse con nucleo e rivestimento a pressione sono state sottoposte a vari test di valutazione fisica e chimica per le compresse con nucleo e rivestimento a pressione. Lo spessore, la durezza e la variazione di peso mostrati da tutte le formulazioni di compresse sono risultati entro i limiti della farmacopea ufficiale. Il rivestimento per compressione � stato effettuato utilizzando Eudragit S 100, Eudragit L 100 ed etilcellulosa come polimeri di rivestimento. I dati relativi al rilascio massimo di farmaco sono stati ottenuti utilizzando una combinazione di polimeri nel rapporto 1:1. Questo libro sar� sicuramente utile per i ricercatori che desiderano progettare e realizzare sistemi di rilascio pulsatile di farmaci per ottenere migliori risultati terapeutici.

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