Probability Models for DNA Sequence Evolution

Richard Durrett

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Language: English

Published by Springer, 2010

1441926771 / 9781441926777

Series: Book 19 of 35 - Probability and Its Applications

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from 'neutral evolution'. The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication.Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes.

Seller Inventory # 9781441926777

Title
Probability Models for DNA Sequence Evolution
Author
Richard Durrett
Publisher
Springer
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
1441926771
ISBN 13
9781441926777
Item weight
668 grams
Dimensions
235x155x24 mm
Series
Book 19 of 35: Probability and Its Applications

AHA-BUCH GmbH

Einbeck, Germany

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AbeBooks seller since August 14, 2006

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