Practical Guide to Hereditary Breast and Ovarian Cancer IV

This book provides updated findings and trends of hereditary breast and ovarian cancer (HBOC) research and clinical practice, offering a comprehensive overview of the latest advancement. It captures the dynamic changes in HBOC treatment, driven by innovations such as poly (ADP-ribose) polymerase inhibitors and BRCA1/2 genetic testing. Key concepts explored include the DNA damage response, precision cancer medicine, and the challenges of regional cooperation in clinical practice. The book also addresses critical issues like homologous recombination deficiency (HRD) testing and the ethical considerations of preimplantation genetic testing. Contributions from leading experts provide insights into the latest evidence and trends, making this book an essential resource for understanding the evolving landscape of HBOC management.

Practical Guide to Hereditary Breast and Ovarian Cancer IV - Annual Meeting of the JOHBOC is written by the authors of the best-chosen works presented at the 4th Annual Meeting in 2024. Designed for breast surgeons, gynecologists, geneticists, and medical staff involved in HBOC practice, this book is also valuable for HBOC patients and their families. With its focus on the latest research and clinical applications, this volume is an indispensable guide for anyone seeking to stay informed about the current state and future directions of HBOC treatment in Japan and the world.

Masami Arai
Masami Arai, MD, graduated from the Department of Medicine at Kagoshima University in 1986. He specializes in clinical genetic medicine for hereditary cancers, such as HBOC, and has worked at the Cancer Institute Hospital (January 2000–March 2018) and Juntendo University (April 2018–present). From 2014 to 2016, he led the Health Labour Sciences Research Grant Research Group on HBOC. During this period, he published the Guidebook for Diagnosis and Treatment of HBOC 2017, which established Japan’s first clinical management guidelines for HBOC. At the same time, he contributed to the development of a nationwide registration system for BRCA1/2 mutation carriers. Currently, he serves as Professor in the Department of Clinical Genetics at Juntendo University and also oversees the institution’s genetic counseling course.

Shinji Ohno
Dr Ohno is the Chairman of Japanese Organization of Hereditary Breast and Ovarian Cancer (JOHBOC).  After postgraduate training at Kyushu University since 1984, he spent three years as a research fellow in the Department of Surgery II at Kyushu University since 1986 and another two years in Internal Medicine at the University of Texas Medical School, U.S.A. since 1989. Then assumed a position as Assistant Professor of the Department of Surgery II at Kyushu University between 1993 and 2000. Was the Director of the Department of Breast Oncology at the National Kyushu Cancer Center from 2000 to 2015.  Since then, he has been Center Chief of Breast Oncology, and Deputy director of Cancer Institute Hospital in Tokyo.  Since 1st September 2023, he has been the director of Sagara Hospital.  Internationally, is a faculty of Advanced Breast Cancer International Consensus Conference,  a member of the Guideline Committee of European Society for Medical Oncology, and an International Advisory Member of The Breast, and a Faculty of American College of Surgeon.

Masayuki Sekine
Department of Obstetrics and Gynecology
Graduate School of Medical Science, University of the Ryukyu
Education: 
2002; Ph.D. Niigata University Graduate School of Medical and Dental Sciences
1994; Graduated, Faculty of Medicine, Niigata University
Professional Experience:
2023 – Present; Professor and Chairman, Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus
2015 – 2023;  Associate Professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
2013 – 2015;  Assistant Professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
2010 – 2013;  Chief Gynecologist, Nagaoka Red Cross Hospital
2006 – 2010;  Assistant Professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
2005 – 2006;  Visiting Fellow, Harvard Institute of Medicine
2002 – 2005;  Assistant Professor, Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences
1998 – 2002;  Graduate Student, Niigata University Graduate School of Medical and Dental Sciences
1997 – 1998;  Resident, Niigata City General Hospital
1996 – 1997;  Resident, Akita Red Cross Hospital
1995 – 1996;  Resident, Saiseikai Kawaguchi General Hospital
1994 – 1995;  Resident, Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital.