A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery
Language: English
Published by Taylor & Francis Inc Dez 2009, 2009
- Hardcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Neuware - Few scientists have access to the multidisciplinary experience needed for successful assay development and high-throughput screening (HTS) in drug discovery. Designed to give researchers a boost, this text integrates the experience of diverse experts who offer fundamental practical guidance across numerous situations. It introduces emerging technology that allows scientists to identify and capture relevant information. It instructs in how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. It also identifies critical targets of relevance in drug discovery and treats each individually in terms of the parameters needed for successful assay development.
Seller Inventory # 9781420070507
- Title
- A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery
- Author
- Taosheng Chen
- Publisher
- Taylor & Francis Inc Dez 2009
- Publication year
- 2009
- Condition
- Neu
- Binding
- Buch
- Language
- English
- ISBN 10
- 1420070509
- ISBN 13
- 9781420070507
- Item weight
- 698 grams
- Dimensions
- 262x186x21 mm
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations.
The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics.
Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.
"Synopsis" may belong to another edition of this title.
About the Author
Taosheng Chen earned a BS in biophysics and an MS in molecular cell biology from Fudan University in Shanghai, China. He received his PhD in cell and molecular biology from the University of Vermont at Burlington. Dr. Chen joined the faculty of the Department of Chemical Biology and Therapeutics and became director of the HTS Center at the St. Jude Children’s Research Hospital in Memphis in 2006. His laboratory focuses on studying the regulation of transcription factors and their implications in drug metabolism and drug resistance as well as in pediatric cancers. Dr. Chen has authored more than 20 peer-reviewed articles in the areas of cancer biology, drug metabolism, signal transduction, and drug discovery technology.
"About the title" may belong to another edition of this title.
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