Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.
The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.
- Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates
- Outlines updated methods and techniques to enumerate conjugation with related case studies
- Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers
Dr. Jitender Madan is Associate Professor and Head of the Department of Pharmaceutics at NIPER Hyderabad, a leading researcher and educator in pharmaceutical sciences. His research centers on self-assembled supramolecular systems―liposomes, niosomes, cyclodextrins, nano- and microparticles, and solid-lipid nanoparticles―and leverages FDA-approved biomaterials with lipids and polymers to develop innovative dosage forms that improve bioavailability, stability, safety, and patient compliance. He has mentored numerous doctoral and postgraduate scholars and led industry collaborations and government-funded projects. Notable products include cycloencapsulated andrographolide for immune support and a veterinary spray for bovine mastitis. He has authored a robust body of peer-reviewed papers and book chapters, holds several patents, and has edited nanotechnology-focused volumes. A recognized educator and researcher, he actively contributes as a peer reviewer and advances pharmaceutical science and education through programs like SRIP.
Whilst a wide range of applications are being taken up, the special emphasis is given to augment the aqueous solubility and bioavailability of lipophilic drugs.
Dr. Ashish Baldi PhD, alumni of Sagar University and Indian Institute of Technology Delhi, is presently working as Professor and Dean, Faculty of Pharmacy MRSPTU, Bathinda. With over 17 years of experience, 3 Patents, 2 Design applications, 8 books, 4 special issues, over 100 national and international publications, 14 book chapters, 35 Invited lectures, several popular articles, more than 160 papers at conferences/ seminars in India and abroad, and several best paper awards to his credit, he is an active researcher in various facets of pharmaceutical sciences and biotechnology. Presently he is supervising 6 research projects granted by various Government agencies like Ministry of AYUSH, DST, ICSSR, ICMR, FITM. He completed 13 major and minor research projects and transferred 2 technologies to leading pharmaceutical industries.
Dr. Monika Chaudhary PhD primary areas of research are drug discovery, design and prodrug formulations in the field of medicinal chemistry. Worked in bio conjugation of anti-cancer drugs and published several research as well review papers in the journals of international repute.
Dr. Neetu Chopra received his PhD in Pharmaceutical Chemistry in 2020. His core area of research covers Design of drug molecules by using Drug designing software’s like Auto dock, V-life sciences, Schrodinger, Computational chemistry, Synthesis of drug molecules, Purification of drug molecules by using Column Chromatography, Chemical libraries, Computational chemistry, Drug discovery and development, Lead optimization, Screening of drug molecules Identification of drug molecules by using different spectral analysis techniques.
