Physiologically Based Pharmacokinetic (PBPK) Modeling : Methods and Applications in Toxicology and Risk Assessment
Language: English
Published by Elsevier Inc Jun 2020, 2020
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
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Seller Inventory # 9780128185964
- Title
- Physiologically Based Pharmacokinetic (PBPK) Modeling : Methods and Applications in Toxicology and Risk Assessment
- Author
- Jeffrey W. Fisher
- Publisher
- Elsevier Inc Jun 2020
- Publication year
- 2020
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 0128185961
- ISBN 13
- 9780128185964
- Item weight
- 600 grams
- Dimensions
- 235x191x18 mm
Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.
- Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology
- Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research
- Authored by expert editors and contributors who are among the best PBPK modelers in the world
"Synopsis" may belong to another edition of this title.
About the Author
Dr. Jeffery M. Gearhart is a Senior Toxicologist with the Henry M. Jackson Foundation for Military Medicine, working in the United States Air Force School of Aerospace Medicine, Aeromedical Department, Wright-Patterson AFB. Dr. Gearhart also is an adjunct professor in the Department of Pharmacology and Toxicology, at the Boonshoft School of Medicine, Wright State University, Dayton, Ohio. He has been a Diplomat of the American Board of Toxicology (DABT) since 1991 and been actively involved in the Society of Toxicology since 1981, a full member since 1990, having served as president and counselor for the Biological Modeling Specialty Section, and counselor for the Inhalation and Respiratory Specialty Section. Dr. Gearhart received his B.S. in Biology from the University of New Mexico and his M.S. while working at the Lovelace Inhalation Toxicology Research Institute, under Dr. Roger O. McClellan. He then studied inhalation and systemic toxicology at the Institute of Environmental Medicine at New York University, with Drs. Richard B. Schesinger and Dr. Morton Lippmann, receiving his Ph.D. in Environmental Health and Toxicology in 1987. Dr. Gearhart practiced corporate toxicology at The Proctor and Gamble Co after working with Drs. Kenneth Crump at the KS Crump Group and Dr. Harvey Clewell III consulting to a wide range of corporate clients in both the private and government sector.
Dr. Zhoumeng Lin is an Associate Professor in the Department of Environmental and Global Health at College of Public Health and Health Professions at the University of Florida. He is a member of the Center for Environmental and Human Toxicology (CEHT) and the Center for Pharmacometrics and Systems Pharmacology (CPSP). He received a B.Med. in Preventive Medicine from Southern Medical University in China in 2009 and a Ph.D. in Toxicology from the University of Georgia in 2013. He completed his postdoctoral training in Computational Toxicology in the Institute of Computational Comparative Medicine at Kansas State University in 2016. He was an Assistant Professor from 2016 to 2021 and then an Associate Professor from March to May 2021 at Kansas State University, prior to joining the University of Florida as an Associate Professor in May 2021. Dr. Lin’s research is focused on the development and application of computational technologies, especially physiologically based pharmacokinetic (PBPK) modeling, machine learning, and artificial intelligence approaches, to study nanomedicine, food safety, nanoparticle and chemical risk assessment. He is a co-author of more than 100 peer-reviewed manuscripts. He teaches two graduate level courses entitled “Physiologically Based Pharmacokinetic Modeling in Toxicology and Risk Assessment and “Artificial Intelligence in Toxicology and Environmental Health.
"About the title" may belong to another edition of this title.
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