Phenotypes and Genotypes

Florian Frommlet

ISBN 10: 1447173805 / ISBN 13: 9781447173809

Published by Springer London, Springer London Mär 2019, 2019

About this Item

Neuware -Thistimely text presents a comprehensive guide to genetic association, a new andrapidly expanding field that aims to elucidate how our genetic code (genotypes)influences the traits we possess (phenotypes). The book provides a detailedreview of methods of gene mapping used in association with experimentalcrosses, as well as genome-wide association studies. Emphasis is placed onmodel selection procedures for analyzing data from large-scale genome scansbased on specifically designed modifications of the Bayesian informationcriterion. Features: presents a thorough introduction to the theoreticalbackground to studies of genetic association (both genetic and statistical); reviewsthe latest advances in the field; illustrates the properties of methods formapping quantitative trait loci using computer simulations and the analysis ofreal data; discusses open challenges; includes an extensive statisticalappendix as a reference for those who are not totally familiar with thefundamentals of statistics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.

Seller Inventory # 9781447173809

Bibliographic Details

• Title: Phenotypes and Genotypes
• Publisher: Springer London, Springer London Mär 2019
• Publication Date: 2019
• Language: English
• ISBN 10: 1447173805
• ISBN 13: 9781447173809
• Binding: Taschenbuch
• Condition: Neu

About this title

Synopsis

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.

About the Author

Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria.

Dr. Małgorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wrocław University, Poland.

Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wrocław University of Technology, Poland.