The Pharmacology of Pain

J. -M. Besson

ISBN 10: 364264550X / ISBN 13: 9783642645501

Published by Springer Berlin Heidelberg, 2011

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Pain is a symptom of many clinical disorders, afflicts a large proportion of the population and is largely treated by pharmacological means. However, the two main classes of drugs used are the opioids and the non-steroidal anti inflammatory drugs, drugs that have a long history. The last decade has seen remarkable advances in our understanding of some of the pharmacological bases of pain and analgesia and this book aims to reflect these rapid changes in our understanding of pain mechanisms. One impetus to these scientific advances has been dialogue and interactions between scientists and clinicians; as a result we now has a number of animal models of clinical pain states, to mimic certain aspects of clinical pathophysiological pain states. Molecular aspects of receptors and the synthesis of tools for probing receptor function have also been rapid growth areas. A number of controlled clinical studies using novel licensed drugs have also resulted from recent research, offering hope to certain patients with severe intractable pain. However, we desperately need the pharmaceutical industry to develop new drugs based on these novel targets for analgesic therapy. This book attempts to provide an overview of the important areas of the pharmacology of pain. This book, although providing an account of the pharmacology of pain transmission and its control based on the underlying anatomical organization and physiological responses, does not attempt to cover these latter two areas.

Seller Inventory # 9783642645501

Bibliographic Details

• Title: The Pharmacology of Pain
• Publisher: Springer Berlin Heidelberg
• Publication Date: 2011
• Language: English
• ISBN 10: 364264550X
• ISBN 13: 9783642645501
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 235W x 155H x 28D millimeters 235 millimeters width by 155 millimeters height by 28 millimeters depth
• Weight: 762 grams

About this title

Synopsis

Pain is a symptom of many clinical disorders, afflicts a large proportion of the population and is largely treated by pharmacological means. However, the two main classes of drugs used are the opioids and the non-steroidal anti­ inflammatory drugs, drugs that have a long history. The last decade has seen remarkable advances in our understanding of some of the pharmacological bases of pain and analgesia and this book aims to reflect these rapid changes in our understanding of pain mechanisms. One impetus to these scientific advances has been dialogue and interactions between scientists and clinicians; as a result we now has a number of animal models of clinical pain states, to mimic certain aspects of clinical pathophysiological pain states. Molecular aspects of receptors and the synthesis of tools for probing receptor function have also been rapid growth areas. A number of controlled clinical studies using novel licensed drugs have also resulted from recent research, offering hope to certain patients with severe intractable pain. However, we desperately need the pharmaceutical industry to develop new drugs based on these novel targets for analgesic therapy. This book attempts to provide an overview of the important areas of the pharmacology of pain. This book, although providing an account of the pharmacology of pain transmission and its control based on the underlying anatomical organization and physiological responses, does not attempt to cover these latter two areas.

About the Author

Pierre Beaulieu, MD, PhD, FRCA, is Associate Professor of Pharmacology and Anesthesiology at the University of Montreal, Quebec, Canada. He received his MD at the University of Bordeaux, trained in anesthesiology in London, UK, and received his PhD in pharmacology in Montreal. His research concentrates on the pharmacology of cannabinoids in the treatment of pain through the modulation of the endocannabinoid system.

David Lussier, MD, obtained his medical degree from the University of Montreal and completed training in pain medicine and palliative care at Beth Israel Medical Center. He is now Associate Professor at University of Montreal, Adjunct Professor at McGill University, a member of McGill's Alan-Edwards Center for Research on Pain, and a physician at the University of Montreal Geriatric Institute and the McGill University Health Center.

Frank Porreca, PhD, is Professor of Pharmacology and Anesthesiology at the University of Arizona. He received his MS in biomedical engineering at Drexel University and his PhD in pharmacology at Temple University. His current research includes mechanisms of neuropathic and other chronic pains, headache pain, opioid-induced hyperalgesia, and new modalities for treatment of pain and drug abuse.

Anthony Dickenson, PhD, FMedSci, is Professor of Neuropharmacology in the Department of Pharmacology at University College, London, UK. He gained his PhD at the National Institute for Medical Research, London, and was appointed to the Department of Pharmacology at University College in 1983. He is a founding and continuing member of the Wellcome Trust-funded London Pain Consortium.