The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems

Language: English

Published by Springer Berlin Heidelberg Okt 2012, 2012

3642630286 / 9783642630286

Series: Book 63 of 124 - Handbook of Experimental Pharmacology

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as 'Curves relating exposure to drugs with biological effects' and 'Implications of monomolecular theory' show Clark's keen insight into the essential questions that required answers to move pharma cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elim inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required. 472 pp. Englisch.…

Seller Inventory # 9783642630286

Title
The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
Author
J. A. Angus
Publisher
Springer Berlin Heidelberg Okt 2012
Publication year
2012
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3642630286
ISBN 13
9783642630286
Item weight
709 grams
Dimensions
235x155x26 mm
Series
Book 63 of 124: Handbook of Experimental Pharmacology

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany