Pathogenicity Islands and the Evolution of Pathogenic Microbes

Kaper James Hacker J.

ISBN 10: 3540426817 / ISBN 13: 9783540426813

Published by Springer, 2002

About this Item

pp. 252.

Seller Inventory # 18348324

Bibliographic Details

• Title: Pathogenicity Islands and the Evolution of Pathogenic Microbes
• Publisher: Springer
• Publication Date: 2002
• Language: English
• ISBN 10: 3540426817
• ISBN 13: 9783540426813
• Binding: Hardcover
• Condition: New

About this title

Synopsis

It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

Review

From the reviews:

"In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ... This compendium ... features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants." (Susanne Rohrer, BioWorld, Issue 6, 2002)