Pain and Neurogenic Inflammation

S.D. Brain

ISBN 10: 3764358750 / ISBN 13: 9783764358754

Published by Springer, Basel, Birkhäuser Basel, Birkhäuser, 1998

About this Item

Neuware - Pain and inflammation are inextricably linked phenomena. The observation that chemical mediators with combined pro-inflammatory, algesic and/or hyperalgesic activity occur at the site of inflammation is fundamental not only to our present understanding of the inflammatory process but also to our attempts to devise clini cally useful anti-inflammatory therapies. Over a hundred years ago it was recognised that primary sensory neurones play a crucially important 'dual' role in inflammation. By affecting the transfer of infor mation from peripheral nociceptors to the spinal cord, a subpopulation of sensory nerves {'pain fibres'} initiate algesia and hyperalgesia, whose sensations are then modified and fine-tuned in the central nervous system. Equally important is the release from the peripheral terminals of sensory neurones of neuropeptides, the acute effects of which are observed as changes in microvascular tone and perme ability leading to neurogenic inflammation. Over the last decade it has become increasingly clear that this view of the func tion of sensory nerves is somewhat over-simplified. For example, the mechanisms underlying hyperalgesia may, in certain circumstances, be mimicked in other condi tions such as the hypersensivity associated with asthma. Furthermore, it has become increasingly evident that over a longer time period the release of neuropeptides from peripheral sensory nerve endings may also have modulating effects on inmune cells and that this may be relevant to chronic inflammatory disease and possibly also to inflammatory hyperalgesia.

Seller Inventory # 9783764358754

Bibliographic Details

• Title: Pain and Neurogenic Inflammation
• Publisher: Springer, Basel, Birkhäuser Basel, Birkhäuser
• Publication Date: 1998
• Language: English
• ISBN 10: 3764358750
• ISBN 13: 9783764358754
• Binding: Buch
• Condition: Neu
• Dimensions: 235W x 155H x 35D millimeters 235 millimeters width by 155 millimeters height by 35 millimeters depth
• Weight: 1510 grams

About this title

Synopsis

Pain and inflammation are inextricably linked phenomena. The observation that chemical mediators with combined pro-inflammatory, algesic and/or hyperalgesic activity occur at the site of inflammation is fundamental not only to our present understanding of the inflammatory process but also to our attempts to devise clini- cally useful anti-inflammatory therapies. Over a hundred years ago it was recognised that primary sensory neurones play a crucially important "dual" role in inflammation. By affecting the transfer of infor- mation from peripheral nociceptors to the spinal cord, a subpopulation of sensory nerves {"pain fibres"} initiate algesia and hyperalgesia, whose sensations are then modified and fine-tuned in the central nervous system. Equally important is the release from the peripheral terminals of sensory neurones of neuropeptides, the acute effects of which are observed as changes in microvascular tone and perme- ability leading to neurogenic inflammation. Over the last decade it has become increasingly clear that this view of the func- tion of sensory nerves is somewhat over-simplified. For example, the mechanisms underlying hyperalgesia may, in certain circumstances, be mimicked in other condi- tions such as the hypersensivity associated with asthma. Furthermore, it has become increasingly evident that over a longer time period the release of neuropeptides from peripheral sensory nerve endings may also have modulating effects on inmune cells and that this may be relevant to chronic inflammatory disease and possibly also to inflammatory hyperalgesia.

Synopsis

This text provides an integrated account of advances in the fields of pain and neurogenic inflammation. The volume is intended to bring together studies from eminent researchers in the often separate research fields of pain and inflammation.