Organic Synthesis: The Disconnection Approach

Warren, Stuart

ISBN 10: 0471101605 / ISBN 13: 9780471101604

Published by John Wiley & Son Ltd, 1982

About this Item

John Wiley & Son Ltd, 1982. Dustjacket very faintly rubbed, spine very barely sunned, raised line on rear flap (pub. flaw); bottom cover edge lightly bumped; edges very faintly soiled, previous owner's stamp along bottom edge; binding tight; dustjacket, cover, and interior intact and clean. hardcover. Good/Good.

Seller Inventory # 596572

Bibliographic Details

• Title: Organic Synthesis: The Disconnection Approach
• Publisher: John Wiley & Son Ltd
• Publication Date: 1982
• Language: English
• ISBN 10: 0471101605
• ISBN 13: 9780471101604
• Binding: Hardcover
• Condition: Good
• Dust Jacket Condition: Good
• Seller catalogs:
  • New Additions

About this title

Synopsis

One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This disconnection approach to synthesis is now a fundamental part of every organic synthesis course.

Organic Synthesis: The Disconnection Approach, 2nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.

Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.

This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control .

Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.

Organic Synthesis: The Disconnection Approach, 2nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.

Review

?The authors have succeeded admirably in the updating of a classic in the pedagogy of organic chemistry.? ( Journal of Medicinal Chemistry , August 2009)

?This book is suitable for advanced undergraduate students, researchers and professional chemists. Both the writing and the diagrams are simple and clear.? ( Reviews, May 2009)