Optimizing the "Drug-Like" Properties of Leads in Drug Discovery (Biotechnology: Pharmaceutical Aspects, IV)

Name: Optimizing the "Drug-Like" Properties of Leads in Drug Discovery (Biotechnology: Pharmaceutical Aspects, IV)
ISBN: 9780387340562

Language: English

Published by Springer, 2006

0387340564 / 9780387340562

Hardcover
Used

See all details

Seller: thebookforest.com, San Rafael, CA, U.S.A.thebookforest.com

4-star seller

AbeBooks seller since January 3, 2023

View this seller's items

Hardcover

Condition: Used - Good

£ 126.79

£ 3.69 shipping

Ships within U.S.A.

Quantity: 1 available

Add to basket

Free 30-day returns

Save for laterCreate a Want for similar items

Seller Inventory # BAY21-00197

Contact seller about this item

Report this item

Title: Optimizing the "Drug-Like" Properties of Leads in Drug Discovery (Biotechnology: Pharmaceutical Aspects, IV)
Publisher: Springer
Publication year: 2006
Condition: Good
Binding: Hardcover
Language: English
ISBN 10: 0387340564
ISBN 13: 9780387340562

Synopsis

Traditionally, incorporating optimal drug-like properties into a structural lead was not considered by medicinal chemists to be their responsibility. Instead, medicinal chemists felt that the undesirable drug-like properties in their drug candidates would be fixed by preclinical development scientists. However, that view has changed in the past 5-10 years, resulting in another significant paradigm shift in drug discovery. The most significant aspect of this latest paradigm shift is the recognition by medicinal chemists that the drug-like properties of structural hits, structural leads, and drug candidates are intrinsic properties of the molecules and that it is the responsibility of the medicinal chemist to optimize not only the pharmacological properties but also the drug-like properties of these molecules. Therefore, assessment of these drug-like properties is now done early in the drug discovery process on structural hits and structural leads as well as the design of screening libraries. Optimization of these drug-like properties is done through an iterative process in close collaboration with preclinical development scientists.

This process is analogous to the process used by the medicinal chemist to characterize and optimize the pharmacological activity of their structural hits, leads and drug candidates. Recognizing these changes in the paradigm by which drugs are discovered, the American Association of Pharmaceutical Scientists (AAPS) has recently organized and sponsored two focused workshops in the area of profiling drug-like properties during drug discovery. The first workshop, entitled "Pharmaceutical Profiling in Drug Discovery for Lead Selection", took place in Whippany, NJ on May 19-21, 2003. This workshop, which was co-sponsored by the American Chemical Society-Medicinal Chemistry Division and the Society for Biomolecular Screening, was focused on prediction, measurement, and utilization of drug-like properties during lead selection. From this workshop arose the book entitled "Pharmaceutical Profiling in Drug discovery for Lead Selection", which was edited by Ronald T. Borchardt, Edward H. Kerns, Christopher A. Lipinski, Dhiren R. Thakker and Binghe Wang and published by AAPS Press (Arlington, VA) in 2004.

The second workshop entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery" took place in Parsippany, NJ on September 19-22, 2004. This workshop, which was co-sponsored by the American Chemical Society-Medicinal Chemistry Division, American Chemical Society-North Jersey Section, American Society for Clinical Pharmacology and Therapeutics, European Federation for Pharmaceutical Sciences, International Society for the study of Xenobiotics, and the Society of Toxicology, was focused on the optimization of the drug-like properties of leads in drug discovery. If the strategies and the methodologies presented at this workshop were to be adopted by pharmaceutical and biotechnology companies, it is the belief of the workshop's organizers that more higher quality drug candidates would be advancing into preclinical and clinical development resulting in more efficacious and safer drugs.

"About the title" may belong to another edition of this title.

thebookforest.com

San Rafael, CA, U.S.A.

4-star seller

AbeBooks seller since January 3, 2023

Shipping rates within U.S.A.

Item	5 to 14 business days	3 to 6 business days
First item	£ 3.69	£ 6.65

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.

Payment methods

Store description

Since 2010, the Book Forest has raised over 3 million dollars for participating public libraries.

Contact sellerView this seller's itemsView seller's storefront

Right of withdrawal

If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.

Information regarding the right of withdrawal

Statutory right to withdraw

You have the right to withdraw from this contract within 14 days without giving any reason.

The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.

To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.

To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.

Effects of withdrawal

If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).

We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.

We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.

We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.

We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.

You shall send back the goods or hand them over to thebookforest.com, San Rafael, California, U.S.A., without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.

Exceptions to the right of withdrawal

The right of withdrawal does not apply to:

The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.

Shipping terms

Orders ship within 24 hours of receipt. Shipping costs are based on books weighing 2.2 LB, or 1 KG. If your book order is heavy or over sized, we may contact you to let you know extra shipping is required.

Optimizing the "Drug-Like" Properties of Leads in Drug Discovery (Biotechnology: Pharmaceutical Aspects, IV)

Bibliographic details

Synopsis

About the title

Synopsis

thebookforest.com

Shipping rates within U.S.A.

Payment methods

Store description

Right of withdrawal

Shipping terms