This is one of the first books that focuses on emerging concepts about the role of the structure of chromatin, the organization of the genome, and the structure of the interphase nucleus in the control of gene expression in eukaryotes. The first section analyses the relationship between the dynamic chromatin structure at the nucleosome level and gene expression. Section two looks into higher order chromatin structure in relation to transcription. In section three the molecular basis of epigenetic phenomena, like X-chromosome inactivation is discussed, starting from our understanding of chromatin structure. Together, these topics form the molecular basis for our understanding of cell differentiation, knowledge that is essential for the design of transgenic animals and plants and for gene therapy in humans. The book is of direct interest to students that are new in the field and to investigators in the area of biomolecular sciences, like developmental biology, biochemistry, cell biology, microbiology and genetics. Also, those working in applied fields of research, i.e biotechnology and biomedicine, will strongly benefit from this book. This book is intended for graduate students, post doctoral scientists and researchers in molecular biology, cell biology, genetics, developmental biology and related disciplines.
"ÝT¨his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene
regulation . . ., and epigenetic regulation of transcription . . . ÝT¨he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding
articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh
perspectives not found in previously published books in this field."--The Quarterly Review of Biology
"[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene
regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding
articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh
perspectives not found in previously published books in this field."--The Quarterly Review of Biology
"[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene
regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding
articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh
perspectives not found in previously published books in this field."--The Quarterly Review of Biology
"[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field."--The Quarterly Review of Biology
"[T]his collection brings together well-written articles covering the critical questions in the field of gene regulation in the context of chromatin. Sixteen chapters discuss three general areas: nucleosome transcriptional repression and remodeling . . ., higher order chromatin structure in gene regulation . . ., and epigenetic regulation of transcription . . . [T]he editors have done a good job in balancing the ability of each chapter to stand alone and minimizing the overlap and redundancy. This allows readers to pick areas of interest without the need to read all of the preceding articles. Most of these chapters provide a basic and relatively current description of each area in chromatin and transcriptional regulation. . . . Overall, this is a great volume that researchers new to the chromatin field will find most useful. I found these articles to contain many fresh perspectives not found in previously published books in this field."--The Quarterly Review of Biology
