A Novel Synthesis Of Isotopically Labelled L-Histidine

Language: English

Published by LAP LAMBERT Academic Publishing Dez 2018, 2018

6139984785 / 9786139984787

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Softcover

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This item is printed on demand - Print on Demand Titel. Neuware -In a few simple steps starting from a commercially available reagents benzyl chloride and potassium thiocyanate, thiocyanate is obtained which is directly reacted with glycine amide to give benzyl thiourea. The used of concentrated HCl give the ring closed product of the latter. The alkylation of 3-benzyl-2- thioxoimidazolidin-4-one is made by the used of methyl iodide under basic condition. Subsequent treatment of the alkyl derivative 3-benzyl-2-(methylthio)-3,5dihydro-4-imidazole with diethyl phosphono cyanate gives the nitrile derivatives which upon treatment with sulphuric acid and functional group manipulations gave 1-benzyl-5-chloromethylimidazolium chloride. This compound is converted mildly under O¿Donnell conditions into the l- Histidine derivative. After deprotection L-Histidine is obtained in good yield with 99% enantiomeric excess. This synthetic scheme allows access to any isotopomer of L-histidine and many other biologically important imidazole derivatives.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 120 pp. Englisch.…

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Bibliographic details

Title
A Novel Synthesis Of Isotopically Labelled L-Histidine
Author
Sarra Talab
Publisher
LAP LAMBERT Academic Publishing Dez 2018
Publication year
2018
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6139984785
ISBN 13
9786139984787
Item weight
197 grams
Dimensions
220x150x8 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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