Novel Drug Delivery Systems For Gene-Targeted RNA Interference : Application of RNAi for Cancer Gene Therapy
Language: English
Published by LAP LAMBERT Academic Publishing, 2010
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 50.82
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - RNA interference refers to sequence-specific messenger RNA degradation initiated by introduction of short RNA duplexes. Since this event results in target-specific gene silencing, siRNAs are expected to serve as potential therapeutic agents to silence disease-causing genes. However, a substantial barrier to the therapeutic application is the delivery of siRNA duplexes into cells. Cyanocobalamin is one of the essential vitamins needed for the division of all cells. Cancer cells especially require abnormally high amounts of cobalamins due to rapid cell division. As a result, the cobalamin receptor density on the surface of the cell is over-expressed. Therefore, a 21 nucleotide long bcr-abl gene-specific siRNA was conjugated to cyanocobalamin, and its uptake, gene-silencing effect, and inhibition of cancer cell proliferation were investigated in K562 human chronic myelogenous leukemia cells. Results and findings discussed in this book indicate to open a door for the potential use of cobalamin as a novel carrier of siRNA for gene-targeted RNA interference.…
Seller Inventory # 9783838340913
- Title
- Novel Drug Delivery Systems For Gene-Targeted RNA Interference : Application of RNAi for Cancer Gene Therapy
- Author
- Randy Adachi
- Publisher
- LAP LAMBERT Academic Publishing
- Publication year
- 2010
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3838340914
- ISBN 13
- 9783838340913
- Item weight
- 221 grams
- Dimensions
- 220x150x9 mm
"Synopsis" may belong to another edition of this title.
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