Non-coding Rna Transcripts in Cancer Therapy : Pre-clinical and Clinical Implications

"Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications" provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.

Dr Gautam Sethi is an Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism (s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted in more than four hundred scientific publications in high impact factor peer reviewed journals and several international awards. He also serves as an editorial board member for several international journals including Antioxidants & Redox Signaling, Cancer Letters, Pharmacological Research, Scientific Reports, International Journal of Cancer, BMC Cancer, Cells, Frontiers in Pharmacology, International Journal of Biological Sciences, International Journal of Oncology, International Journal of Cancer, Journal of Functional Foods, PLOS One, and ad-hoc reviewer for several other prestigious international journals. He is currently also ranked among the world's most highly cited scientists according to the list of Highly Cited Researchers™ released in both 2020 and 2021 by Clarivate.

Dr Milad Ashrafizadeh is a researcher in Sabanci university, Turkey and obtained his degree in field of Veterinary Medicine in 2020. He is an invited scholar in University of Electronic Science & Technology of China. Currently, Milad is an Editorial Board in journal of nanostructure in chemistry (IF= 6.39) and is a review editor in Frontiers journals. He has published review and research articles in international and famous journals in world. Milad has also 4 book chapters. He has published articles in high quality journals including Nanotoday, Coordination Chemistry Reviews, Advanced Science, Carbohydrate Polymers, Journal of Controlled Release and Advances in Colloid and Interface Science, among others. His interests include nanomedicine, application of nanoparticles for drug and gene delivery, targeted cancer therapy, non-coding RNAs in cancer and development of biosensors.