Nitric Oxide No and Cancer : Prognosis, Prevention, and Therapy
Language: English
Published by Humana, 2012
Series: Book 63 of 96 - Cancer Drug Discovery and Development
- Softcover
- New
Seller: GreatBookPrices, Columbia, MD, U.S.A.GreatBookPrices
AbeBooks seller since April 6, 2009
Condition: New
£ 198.51
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- Title
- Nitric Oxide No and Cancer : Prognosis, Prevention, and Therapy
- Author
- Bonavida, Benjamin (EDT)
- Publisher
- Humana
- Publication year
- 2012
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 1461426111
- ISBN 13
- 9781461426110
- Series
- Book 63 of 96: Cancer Drug Discovery and Development
Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.
"Synopsis" may belong to another edition of this title.
From the Back Cover
The Nobel Prize in Physiology and Medicine was awarded in 1998 to Doctors Furchgott, Ignarro, and Murad for their discoveries concerning "Nitric oxide (NO) as a signaling molecule in the cardiovascular system." NO-inducing cell signaling events within the cell producing it and the diffusibility to NO in other cells have led to the discovery of many other physiological functions in many different types of cells including cancer. Noteworthy, nitroglycerin that has been used for the treatment of chest pain and associated cardiovascular diseases is currently being investigated for its therapeutic effect in clinical studies in patients with cancer. Further, several NO donor compounds have shown, in preclinical studies, anti-tumoral chemopreventive and therapeutic activities.
"Nitric Oxide and Cancer: Prognosis, Prevention and Therapy", edited by Benjamin Bonavida, Ph.D., reviews several novel applications of NO in cancer, a new field that has rapidly gained credibility and understanding at the biochemical and molecular levels. The various chapters in this comprehensive volume (25 contributions), written by noted experts in the field, bring up-to-date our current understanding and prospective future clinical applications of NO.
"About the title" may belong to another edition of this title.
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