Synopsis
Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra- porter proteins that have been studied intensely over the last 30 years; this information is scattered throughout numerous publishing vehicles. Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles. The transporter field has moved forward in stages. In the first phase, progress came from the use of substrate or blocker ligands selectively targeting transporters, the application of model systems allowing the study of transmitter tra- port shielded from storage, and the development of mathematical models for describing transport phenomena. In the second phase, roughly covering the last decade, advances in DNA techniques allowed the cloning of numerous genes coding for different transporter proteins. In the current, third stage, a wealth of information is being accumulated in studies relating transporter structure with function, experiments addressing regulation by posttranslational transfor- tion, investigations into transport modulation by trafficking processes and genomic influences, characterization of channel properties of tra- porters by electrophysiological approaches, and the creation of transgenic animals under- or overexpressing a given transporter protein.
From the Back Cover
Integrating the many recent advances from DNA technology, Maarten Reith and his contributors fully update all the material in his highly acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis studies, and transporter electrophysiology. Many chapters will be of interest to physicians carrying out imaging and postmortem measurements of neurotransmitter transporters in the human brain, and to physicians who study the relation of gene linkages and polymorphisms to psychiatric and other complex human diseases.
Complete and up-to-date, Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of this most active field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move work on another transporter forward.
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