Up-to-date third edition which presents a coherant description of the nervous system from the perspective of modern work on molecular biology, cellular and developmental biology, biophysics, neurophysiology, neurochemistry and neuroanatomy. The scope of the book has been broadened with entirely new chapters on the biophysics and molecular biology of membrane channels, indirect mechanisms of synaptic transmission, the cellular and molecular biology of synaptic transmission, nervous system development, sensory receptors and systems, and motor systems. To accommodate this new information other subjects have been abbreviated or ammalgamated. Permeating the book are new concepts derived from experiments at the molecular level. Techniques such as patch clamping, gene cloning and expression, the use of monoclonal antibodies, and site-directed mutagenesis not only deepen but often simplify the presentation of topics related to signaling, synapse transmission, plasticity and development.
Contents PART I. INTRODUCTION
Principles of Signaling and Organization
PART II. SIGNALING IN THE NERVOUS SYSTEM
Ion Channels and Signaling
Structure of Ion Channels
Transport across Cell Membranes
Ionic Basis of the Resting Potential
Ionic Basis of the Action Potential
Neurons as Conductors of Electricity
Properties and Functions of Neuroglial Cells
Principles of Direct Synaptic Transmission
Indirect Mechanisms of Synaptic Transmission
Transmitter Release
Synaptic Plasticity
Cellular and Molecular Biochemistry of Synaptic Transmission
Neurotransmitters in the Central Nervous System
PART III. INTEGRATIVE MECHANISMS
Cellular Mechanisms of Integration and Behavior in Leeches, Ants, and Bees
Autonomic Nervous System
Transduction of Mechanical and Chemical Stimuli
Processing of Somatosensory and Auditory Signals
Transduction and Signaling in the Retina
Analysis of Form in Primary Visual Cortex
Functional Architecture of the Visual Cortex
Cellular Mechanisms of Motor Control
PART IV. DEVELOPMENT OF THE NERVOUS SYSTEM
Development of the Nervous System
Denervation and Regeneration of Synaptic Connections
Critical Periods in Visual and Auditory Systems
PART V. CONCLUSION
Open Questions