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Neurogenesis in the Adult Brain I

Arturo Alvarez-Buylla

Published by Springer Jul 2011, 2011
ISBN 10: 4431539328 / ISBN 13: 9784431539322
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Title: Neurogenesis in the Adult Brain I

Publisher: Springer Jul 2011

Publication Date: 2011

Binding: Buch

Book Condition: Neu


Neuware - (Tentative) For more than one hundred years, it has been believed that neurons are never generated in the adult mammalian brain, and that neurogenesis in the mammalian brain occurs only during embryonic and early postnatal stages and ceases before puberty. Recently, however, this paradigm has been shifted. Several lines of evidence have shown that neurons continue to be generated in some special adult brain regions such as the hippocampus and subventricular zone of the forebrain in mammals including humans. The new paradigm raises the possibility of therapeutic neuron replacement in degenerative diseases or brain trauma. This book will be the first to illustrate major advances in the field of adult neurogenesis and their possible application to the therapies for brain diseases. 432 pp. Englisch. Bookseller Inventory # 9784431539322

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The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

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