Neurodevelopmental Disorders : Employing iPSC Technologies to Define and Treat Childhood Brain Diseases

Name: Neurodevelopmental Disorders : Employing iPSC Technologies to Define and Treat Childhood Brain Diseases
Author: DiCicco-Bloom, Emanuel (Edited by)/ Millonig, James H. (Edited by)
ISBN: 9783030454920

DiCicco-Bloom, Emanuel (Edited by)/ Millonig, James H. (Edited by)

Language: English

Published by Springer, 2020

3030454924 / 9783030454920

Series: Book 1 of 39 - Advances in Neurobiology

Hardcover
New

See all details

Seller: Revaluation Books, Exeter, United KingdomRevaluation Books

5-star seller

AbeBooks seller since January 6, 2003

View this seller's items

Hardcover

Condition: New

£ 200.55

£ 12.50 shipping

Ships from United Kingdom to U.S.A.

Quantity: 2 available

Add to basket

Free 30-day returns

Save for laterCreate a Want for similar items

Item description from seller

1st edition. 305 pages. 9.75x6.50x0.75 inches. In Stock.

Seller Inventory # x-3030454924

Contact seller about this item

Report this item

Title: Neurodevelopmental Disorders : Employing iPSC Technologies to Define and Treat Childhood Brain Diseases
Author: DiCicco-Bloom, Emanuel (Edited by)/ Millonig, James H. (Edited by)
Publisher: Springer
Publication year: 2020
Condition: Brand New
Binding: Hardcover
Language: English
ISBN 10: 3030454924
ISBN 13: 9783030454920
Item weight: 0.64 kilograms
Series: Book 1 of 39: Advances in Neurobiology

About the Author

Emanuel DiCicco-Bloom, M.D. is Professor of Neuroscience and Cell Biology and Pediatrics (Child Neurology & Neurodevelopmental Disabilities) at Rutgers Robert Wood Johnson Medical School (RWJMS) in New Jersey and a member of graduate programs in Cell & Developmental Biology, Neuroscience, and Toxicology at Rutgers University. He graduated summa cum laude from Princeton University, received his M.D. from then Cornell University Medical College, and trained in Pediatrics and Neurology at New York Hospital-Cornell Medical Center, joining RWJMS in 1990.

Dr. DiCicco-Bloom has broad experience performing basic and translational research on neurodevelopmental disorders including animal models and human induced pluripotent stem cells (iPCSs). As an active child neurologist, his research focuses on defining molecular and cellular pathways that regulate production of neuronal cells (neurogenesis) during brain development, and how related abnormalities contribute to developmental disorders including autism. He investigates how growth signals, genetic factors, and environmental toxins impact cell proliferation, survival, and fate determination during brain development using rat and mouse neural stem cells in culture and in vivo, with a focus on the cerebral cortex, cerebellum, and hippocampus. To begin defining mechanisms that are more directly relevant to human disorders, recent collaborative studies with Co-Editor James H. Millonig, Ph.D. have focused on creating human induced neural stem cells (NPCs) from people with autism, to determine their neurobiological signatures. Significantly, by comparing NPCs from two forms of autism, including idiopathic and genetically defined (CNV 16p11.2 Deletion Syndrome), these studies reveal a common neurobiological phenotype consisting of reduced neural process outgrowth and cell migration in autism compared to control NPCs. Moreover dysregulation of the mTOR signaling pathway appears to be central to these phenotypes, as pathway manipulation both corrects autism deficits and recreates abnormalities in relevant controls. This new era of exploring neuropsychiatric conditions in human neurons may provide more relevant cellular and molecular pathways on which to target therapeutic interventions that may be “personalized” to the needs of the specific individual.

Dr. DiCicco-Bloom has long served the autism scientific and advocacy communities, providing scientific expertise to federal agencies including NIH, DOD, NSF, and IACC, and disease advocacy organizations including National Alliance for Autism Research, Autism Science Foundation, Autism Speaks, Autism Tissue Program, Brain Canada, Rett Syndrome Foundation, and Simons Foundation. He Chaired the Scientific Program Committee of the 2008 International Meeting for Autism Research (IMFAR) meeting (London) and Co-Chaired 2010 (Philadelphia), and has long served the IMFAR Program Committee. For the Society for Neuroscience, he has served on many committees (PECC, GPA, Audit, Rigor and Reproducibility Working Group) and as a Councilor. Currently, he is Chair of the NIH Developmental Brain Disorders Study Section, is a member of the DOD Autism Research Program and the American Brain Coalition (ABC) Board of Directors, and serves as Scientific Advisor to the Eagles Autism Foundation. He serves on the editorial boards of Autism Research, Molecular Autism, and other developmental neuroscience journals, and has authored numerous research articles and book chapters in neuroscience, child neurology, and psychiatry.

James H. Millonig Ph.D. is associate professor in the department of Neuroscience and Cell Biology and resident member in the Center for Advanced Biotechnology and Medicine at Robert Wood Johnson Medical School-Rutgers University.

Dr. Millonig graduated from The University of Rochester magna cum laude with a B.S. in Biochemistry. After college he received a M.Sc. degree from Oxford University, University College studying B subtilis sporulation. Dr. Millonig matriculated in the Princeton University Molecular Biology PhD program and performed his thesis research in the lab of Shirley Tilghman Ph.D., President emerita of Princeton University. During his PhD, he was trained in genetics, mouse development, and molecular biology. Subsequent post-doctoral research, using mouse genetic approaches to study cerebellar development, was performed in Mary E. Hatten’s laboratory at The Rockefeller University. He joined the faculty at Rutgers in 1999.

Dr. Millonig has studied CNS development throughout his career applying molecular genetic approaches to understand basic mechanisms and disease. His work in collaboration with Emanuel DiCicco-Bloom M.D. and Linda Brzustowicz M.D. demonstrated genetic association of ENGRAILED2 (EN2) with autism spectrum disorder and defined autism-like behaviors in mouse models thatcould be reversed by pharmacological treatment. His lab also identified the orphan GPCR, Gpr161, as an unknown, important regulator of neural tube closure and lens development. Forward mouse genetic approaches demonstrated that Gpr161 functions through the retinoic acid (RA) pathway. His lab is currently studying rare human mutations in the RA metabolic pathway and Gpr161 and their impact on development. More recently, Dr. Millonig and Dr. DiCicco-Bloom have applied iPSC-based approaches to study idiopathic and 16p11.2 Deletion Syndrome. They have defined neurodevelopmental phenotypes in culture and are applying numerous omic strategies to define the downstream signaling and cell biological pathways affected in autism. He is the recipient of many research awards including Basil O’Connor Starter Research Award, NARSAD Young Investigator Award, and the Thomas A Edison Patent Award for medical diagnostics. He has over 100 abstracts, papers, and grants related to autism and neurodevelopmental disorders. He has been an active reviewer for many scientific journals including Molecular Psychiatry, Translational Psychiatry, and eLife. For the NIH, he has been an ad hoc member of Clinical Neuroplasticity and Neurotransmitters and Genetics of Health and Disease, was a standing member of the NIH Developmental Brain Disorders Study Section (2010-16) and has also contributed to NIH Loan Repayment Program, BRAIN, and NIH Director’s Early Independence Awards initiatives.

He is currently the Director of the Rutgers-RWJMS-Princeton University MD/PhD program and is senior associate dean in the Rutgers School of Graduate Studies. He was co-PI on an NIH Director’s Fund Broadening Experiences Scientific Training (BEST) training grant. In these roles, Dr. Millonig has developed numerous educational initiatives including the BEST program called iJOBS, which includes all Rutgers campuses across NJ that has reached 836 trainees or 16,258 person hours in 4 years.

"About the title" may belong to another edition of this title.

Revaluation Books

Exeter, United Kingdom

5-star seller

AbeBooks seller since January 6, 2003

Shipping rates from United Kingdom to U.S.A.

Item	7 to 14 business days	2 to 3 business days
First item	£ 12.50	£ 30.00

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.

Payment methods

Seller's business information

Edward Bowditch Ltd

Exstowe, Exton
Exeter, United Kingdom EX3 0PP

Contact sellerView this seller's itemsView seller's storefront

Terms of sale

Legal entity name: Edward Bowditch Ltd
Legal entity form: Limited company
Business correspondence address: Exstowe, Exton, Exeter, EX3 0PP
Company registration number: 04916632
VAT registration: GB834241546
Authorised representative: Mr. E. Bowditch

Right of withdrawal

If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.

Information regarding the right of withdrawal

Statutory right to withdraw

You have the right to withdraw from this contract within 14 days without giving any reason.

The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.

To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.

To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.

Effects of withdrawal

If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).

We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.

We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.

We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.

We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.

You shall send back the goods or hand them over to Revaluation Books, Hounslow, United Kingdom, without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.

Exceptions to the right of withdrawal

The right of withdrawal does not apply to:

The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.

Shipping terms

Orders usually dispatched within two working days.