NMDA Antagonists as Potential Analgesic Drugs

Dalip J.S. Sirinathsinghji

ISBN 10: 3764360119 / ISBN 13: 9783764360115

Published by Springer, Basel, Birkhäuser Basel Jan 2002, 2002

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca demic and pharmaceutical laboratories to identify novel pain targets and to devel op novel analgesic drugs. It is clear from numerous studies that the NMDA recep tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol ume is very timely. 194 pp. Englisch.

Seller Inventory # 9783764360115

Bibliographic Details

• Title: NMDA Antagonists as Potential Analgesic Drugs
• Publisher: Springer, Basel, Birkhäuser Basel Jan 2002
• Publication Date: 2002
• Language: English
• ISBN 10: 3764360119
• ISBN 13: 9783764360115
• Binding: Buch
• Condition: Neu
• Dimensions: 23.5W x 15.5H x 0D centimeters 23.5 centimeters width by 15.5 centimeters height by 0 centimeters depth
• Weight: 600 grams

About this title

Synopsis

There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. L

Synopsis

There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. Leading scientists in excitatory amino acid and analgesia research have compiled in this volume the most recent information on molecular biology, physiology and pharmacology of NMDA receptors, their neuroanatomical localisation within specific neural pathways involved in nociception, and experimental and clinical evidence demonstrating the potential of receptor antagonists of NMDA and other excitatory amino acids in the treatment of pain states. This multidisciplinary, multistrategied approach to the study of NMDA receptors in pain processing is unique. The intriguing research into the role of NMDA receptors in modulation of pain will be of interest to neuroanatomists, neurophysiologists, neuropharmacologists, neurologists and researchers in the pharmaceutical industry.