The Multiple Inert Gas Elimination Technique (MIGET) is a complex methodology involving specialized gas chromatography and sophisticated mathematics developed in the early 1970’s. Essentially, nobody possesses knowledge of all its elements except for its original developers, and while some practical and theoretical aspects have been published over the years, none have included the level of detail that would be necessary for a potential user to adopt and understand the technique easily. This book is unique in providing a highly detailed, comprehensive technical description of the theory and practice underlying the MIGET to help potential users set up the method and solve problems they may encounter.

But it is much more than a reference manual – it is a substantial physiological and mathematical treatise in its own right.

It also has a wide applicability – there is extensive discussion of the common biological problem of quantitative inference. The authors

took measured whole-lung gas exchange variables, and used mathematical procedures to infer the distribution of ventilation and blood flow from this data. In so doing, they developed novel approaches to answer the question: What are the limits to what can be concluded when inferring the inner workings from the “black box” behavior of a system? The book details the approaches developed, which can be generalized to other similar distributed functions within tissues and organs. They involve engineering approaches such as linear and quadratic programming, and uniquely use mathematical tools with biological constraints to obtain as much information as possible about a “black box” system.

Lastly, the book summarizes the hundreds of research papers published by a number of groups over the decades in a way never before attempted in order to marshal the world’s literature on the topic and to provide in one place the wealth of important discoveries, both physiological a

ndclinical, enabled by the technique.

About the Author

Susan R. Hopkins MD PhD is a Professor of Medicine and Radiology at the University of California, San Diego. For over 30 years she has been studying the lung under conditions of stress: hypoxia, high altitude exercise and lung disease. After receiving her MD degree from Memorial University of Newfoundland, she graduated from the University of British Columbia with a Fellowship in Sports Medicine and a PhD in exercise physiology. Her interest in pulmonary gas exchange led her to UCSD in 1993 to work with Peter Wagner and learn MIGET first-hand, a collaboration which continues to this day. In addition to work in human athletes and patients, she has also explored the relationship between lung structure and gas exchange during exercise in a number of non-human species including monitor lizards, horses and emus, showing that across these divergent species ventilation-perfusion matching is remarkably well preserved. Recent work focuses on the use of functional proton MRI to characterize lung ventilation, perfusion and ventilation-perfusion matching in health and disease. She is an Associate Editor of Applied Physiology Nutrition and Metabolism and the European Journal of Applied Physiology. She also serves on the NIH MEDI study section.

Dr. Peter D. Wagner is Emeritus Distinguished Professor of Medicine & Bioengineering at the University of California, San Diego in La Jolla, CA. After obtaining his M.B., B.S. and B.Sc. (Medicine) degrees from Sydney University in 1968, he did postdoctoral work with Professor John West at UCSD in La Jolla, CA, USA. He then joined the UCSD medical faculty and has remained there to the present time. His research addresses the theoretical and experimental basis of oxygen transport and its limitations in the lungs and skeletal muscles in health and disease. Many years ago, he developed the Multiple Inert Gas Elimination Technique for determining the distribution of ventilati

on and blood flow throughout the lungs. A more recent focus is on how the O2 transport system - the lungs, heart, blood and muscles - functions in an integrated manner to limit maximal VO2. He also works on muscle capillary growth regulation using molecular biological approaches in isolated muscle as well as in the intact mouse and human. Of particular interest is the role of VEGF in this process. He has served NIH as a study section member and chair, professional societies as an Associate Editor of the Journal of Clinical Investigation and also of the Journal of Applied Physiology, was President of the American Thoracic Society 2005-2006, and was President of the American Physiological Society in 2010. He was Editor in Chief of the Journal of Applied Physiology from 2011-2017, and is current chair of the NIH Physiology and Pathobiology of Cardiovascular and Respiratory Systems individual NRSA grants study section. He has published more than 360 peer-reviewed research articles and over 145 invited chapters andother contributions.

"About this title" may belong to another edition of this title.

Store Description

We carry a comprehensive range of out of print and rare books.

Visit Seller's Storefront

Seller's business information

Kennys Bookshops and Art Galleries Limited
Liosban Industrial Estate, Tuam Road, Galway, GY, Ireland

Sale & Shipping Terms

Terms of Sale

We guarantee the condition of every book as it's described on the Abebooks websites.

If you're dissatisfied with your purchase (Incorrect Book/Not as Described/Damaged) or if the order hasn't arrived, you're eligible for a refund within 30 days of the estimated delivery date.

For any queries please use the contact seller link or send an email to books@kennys.ie

Conor Kenny

Right of cancellation

If you are a consumer you can cancel the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.

INFORMATION REGARDING THE RIGHT OF CANCELLATION

Statutory Right to cancel

You have the right to cancel this contract within 14 days without giving any reason.

The cancellation period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the the last good or the last lot or piece.

To exercise the right to cancel, you must inform us, Kennys Bookstore, The Museum at Tall Timbers, 2707 Olney - Sandy Spring Road, 20832, Olney, Maryland, U.S.A., +353 91709350, of your decision to cancel this contract by a clear statement (e.g. a letter sent by post, fax or e-mail). You may use the attached model cancellation form, but it is not obligatory. You can also electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". If you use this option, we will communicate to you an acknowledgement of receipt of such a cancellation on a durable medium (e.g. by e-mail) without delay.

To meet the cancellation deadline, it is sufficient for you to send your communication concerning your exercise of the right to cancel before the cancellation period has expired.

Effects of cancellation

If you cancel this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).

We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.

We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to cancel with contract.

We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.

We may withhold reimbursement until we have received the goods back or you have supplied evidence of having sent back the goods, whichever is the earliest.

You shall send back the goods or hand them over to us or Kennys Bookstore, The Museum at Tall Timbers, 2707 Olney - Sandy Spring Road, 20853, Olney, Maryland, U.S.A., +353 91709350, without undue delay and in any event not later than 14 days from the day on which you communicate your cancellation from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.

Exceptions to the right of cancellation

The right of cancellation does not apply to:

the delivery of newspapers, journals or magazines with the exception of subscription contracts; and
the supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not cancel it once delivery had started.

Model withdrawal form

(complete and return this form only if you wish to withdraw from the contract)

To: (Kennys Bookstore, The Museum at Tall Timbers, 2707 Olney - Sandy Spring Road, 20832, Olney, Maryland, U.S.A., +353 91709350)

I/We (*) hereby give notice that I/We (*) withdraw from my/our (*) contract of sale of the following goods (*)/for the provision of the following goods (*)/for the provision of the following service (*),

Ordered on (*)/received on (*)

Name of consumer(s)

Address of consumer(s)

Signature of consumer(s) (only if this form is notified on paper)

Date

* Delete as appropriate.

Shipping Terms

All books securely packaged. Some books ship from Ireland.

Shipping rates within U.S.A.

Shipping rates within U.S.A.
Order quantity	14 to 20 business days	13 to 14 business days
First item	� 7.83	� 15.66

Delivery times are set by sellers and vary by carrier and location. Orders passing through Customs may face delays and buyers are responsible for any associated duties or fees. Sellers may contact you regarding additional charges to cover any increased costs to ship your items.