Molecularly Imprinted Receptor Targeting Lung Cancer Biomarker : Imprinted Polymers for Affinity based Extractions of a Peptidic Biomarker from Protein Digests
Language: English
Published by LAP LAMBERT Academic Publishing, 2014
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 68.93
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Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - The early diagnosis of biomarker is crucial for patient survival and successful prognosis of the disease, and for this reason sensitive and specific methods are required for early cancer diagnosis. However, common techniques for separation and concentrating biomarker are not optimal from the viewpoints of sensitivity and selectivity because analyzing these biomarkers from a small amount of serum is difficult due to the complexity of the sample and low levels of these biomarkers. Peptide imprinted polymers were developed for detection of progastrin releasing peptide (ProGRP); a low abundant blood based biomarker for small cell lung cancer. Peptide imprinted polymers with the best affinity characteristics were first identified from a 96-polymer combinatorial libraries. The effects of monomers, crosslinker, porogen, and template on adsorption capacity and selectivity for nonapeptide sequence NLLGLIEAK resulting from tryptic digestion were investigated and optimized. Ultimately, a solid phase extraction method was developed for highly selective enrichment of the target peptide from tryptic digests.…
Seller Inventory # 9783659570155
- Title
- Molecularly Imprinted Receptor Targeting Lung Cancer Biomarker : Imprinted Polymers for Affinity based Extractions of a Peptidic Biomarker from Protein Digests
- Author
- Abed Abdel Qader
- Publisher
- LAP LAMBERT Academic Publishing
- Publication year
- 2014
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 365957015X
- ISBN 13
- 9783659570155
- Item weight
- 268 grams
- Dimensions
- 220x150x11 mm
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