Molecular Analysis of DNA Rearrangements in the Immune System
Language: English
Published by Springer Berlin Heidelberg, 2012
Series: Book 204 of 322 - Current Topics in Microbiology and Immunology
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 47.24
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Add to basketItem description from seller
Druck auf Anfrage Neuware - Printed after ordering - The vertebrate immune system is distinctive among defense systems of multicellular organisms. In addition to nonspecific immunity, it generates a randomized array of millions of antigen receptors (immunoglobulins and T-cell receptors). A subset of these receptors are critical for binding to invading microbes or biochemicals from them to tag the microbes for elimination. Three site-directed DNA modification processes are critical to this process in vertebrates. V(D)J recombination generates the array of exons that encode the antigen binding pockets. Recent work summarized in this volume describes the dissection of this process at the biochemical level. The mechanism of the reaction is now understood in considerable detail. The proteins that catalyze many steps of the process have now been identified by biochemical and genetic recon stitution and by analysis of genetic mutants defective in V(D)J recombination. Class switch recombination is the process by which the variable domain exon of the heavy chain is changed from IgM to IgG, IgA. or IgE. Recent progress is described in the de velopment of an extrachromosomal substrate assay system. Molecular genetic analysis of the process in transgenics is defining some of the cis sequence requirements. Biochemical assays for defining enzymatic components are also described. In addition to exciting progress in V(D)J recombination and class switch recombination, one chapter describes recent pro gress in somatic hypermutation.…
Seller Inventory # 9783642501425
- Title
- Molecular Analysis of DNA Rearrangements in the Immune System
- Author
- Michael R. Lieber
- Publisher
- Springer Berlin Heidelberg
- Publication year
- 2012
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3642501427
- ISBN 13
- 9783642501425
- Item weight
- 371 grams
- Dimensions
- 235x155x14 mm
- Series
- Book 204 of 322: Current Topics in Microbiology and Immunology
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