Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters)
Language: English
Published by Springer Spektrum 2017-12-13, 2017
Series: Book 53 of 91 - BestMasters
- Softcover
- New
Seller: Chiron Media, Wallingford, United KingdomChiron Media
AbeBooks seller since August 2, 2010
Condition: New
£ 47.27
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Add to basketSeller Inventory # 6666-IUK-9783658201661
- Title
- Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters)
- Author
- Sabine Stbler
- Publisher
- Springer Spektrum 2017-12-13
- Publication year
- 2017
- Condition
- New
- Binding
- Paperback
- Language
- English
- ISBN 10
- 3658201665
- ISBN 13
- 9783658201661
- Series
- Book 53 of 91: BestMasters
Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
"Synopsis" may belong to another edition of this title.
About the Author
Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.
"About the title" may belong to another edition of this title.
Chiron Media
Wallingford, United Kingdom
AbeBooks seller since August 2, 2010
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