Microstructured Interpenetrating Polymer Network Drug Delivery System : Development of Novel Interpenetrating Polymer Network Hydrogel Microspheres For Controlled Release of Diclofenac Sodium
Language: English
Published by LAP LAMBERT Academic Publishing, 2011
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
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nach der Bestellung gedruckt Neuware - Printed after ordering - Novel interpenetrating network (IPN) hydrogel microspheres, consisting of xanthan gum and poly(vinyl alcohol) were prepared by water-in-oil emulsion crosslinking method using glutaraldehyde for the controlled release of diclofenac sodium,as a model drug.Various formulations were prepared by changing the ratio of XG:PVA, extent of cross-linking in order to optimize the formulation variables on drug encapsulation efciency, and release rate. Formation of IPN and the chemical stability of DS after preparation of microspheres was confrmed by FTIR, DSC & XRD analysis were done which confrmed molecular dispersion of DS in the IPN. Microspheres formed were spherical with smooth surfaces, as evidenced by SEM & mean particle size measured by laser light scattering technique. Drug encapsulation of up to 82.94% was achieved by UV method. Both equilibrium & dynamic swelling studies and in vitro release studies were performed in pH 1.2 and 7.4. Release data indicated Fickian trend of drug release. In vivo pharmacokinetic data showed prolonged drug release as compared with DS solution. Based on the results it was concluded that these IPN microspheres provided controlled release application of DS.…
Seller Inventory # 9783846524398
- Title
- Microstructured Interpenetrating Polymer Network Drug Delivery System : Development of Novel Interpenetrating Polymer Network Hydrogel Microspheres For Controlled Release of Diclofenac Sodium
- Author
- Subham Banerjee
- Publisher
- LAP LAMBERT Academic Publishing
- Publication year
- 2011
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- English
- ISBN 10
- 3846524395
- ISBN 13
- 9783846524398
- Item weight
- 209 grams
- Dimensions
- 220x150x9 mm
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