Microfluidic Cell Culture Systems (Micro and Nano Technologies)
Language: English
Published by Elsevier, 2019
- Softcover
- Used
Seller: killarneybooks, Inagh, Clare, Irelandkillarneybooks
AbeBooks seller since April 20, 2017
Condition: Used - Very good
£ 66.60
Quantity: 1 available
Add to basketItem description from seller
Oversized paperback, second edition, xv + 380 pages, NOT ex-library. Signs of light wear; book is clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. Straight spine. -- This is a technical manual for designing and using Organ-on-a-Chip technology. It focuses on the intersection of microfabrication and cell biology, providing the engineering blueprints needed to create miniature, functional models of human organs. Core Objectives: - Engineering 3D Environments: It explains how to move beyond flat Petri dishes to create 3D micro-environments that mimic the physical and chemical conditions inside the human body; - Disease Modelling: A major focus is the development of specific models for drug toxicity testing and disease progression, particularly for the liver and lung. - Scale-Up for Industry: It addresses the "translation" problem - how to move a delicate microfluidic device from a university lab to a mass-produced industrial tool for pharmaceutical screening. Technical Breakdown: - Micro-scale Physics: The text details how fluids behave at the micron level, focusing on laminar flow, shear stress, and nutrient delivery to living cells. - Biomaterials: It reviews the materials used to build these systems (such as PDMS and other polymers) and how to ensure they are biocompatible so they do not kill the cells they are meant to house. - Multi-Organ Systems: The book explores "Body-on-a-Chip" concepts, where multiple organ models are connected by micro-channels to simulate how a drug might move from the gut to the liver and eventually the bloodstream. It serves as a bridge for engineers who understand fluid dynamics but need to learn cell biology, and for biologists who understand disease but need the hardware to simulate it accurately without using animal models.…
Seller Inventory # 013026
- Title
- Microfluidic Cell Culture Systems (Micro and Nano Technologies)
- Author
- Jeffrey T. Borenstein; Vishal Tandon; Sarah L. Tao; Joseph L. Charest
- Publisher
- Elsevier
- Publication year
- 2019
- Condition
- Very Good
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 0128136715
- ISBN 13
- 9780128136713
- Edition
- 2nd Edition
- Series
- Book 165 of 393: Micro and Nano Technologies
Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems.
This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems.
This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances.
"Synopsis" may belong to another edition of this title.
About the Author
Vishal Tandon is a Research Fellow at the Biomedical Engineering Center, Draper University, USA. His research focuses on the design and testing of implantable microfluidic devices for drug delivery into the ear.
Sarah Tao is Senior Manager, New Technologies at CooperVision, Inc. She was previously Senior Member Technical Staff, MEMS Design Group at Draper University, and Research Professor Equivalent, Bioengineering and Therapeutic Sciences at the University of California, San Francisco, USA. Her research interests lie in the areas of biomaterials, nanotechnology, regenerative medicine, drug delivery, BioMEMS, microfluidics and cell culture.
Dr. Charest is director of in vitro model and organ-assist work at Draper Laboratory. The work of his teams leverages micro- and nano-fabrication along with advanced machining techniques to create systems which recapitulate native tissue and organ architecture, morphology, and function in vitro. The systems span applications from medical devices to screening platforms for pharmaceuticals, and impact fields of use in various organ and tissue types such as tumor, kidney, vascular tissue and lung. Dr. Charest graduated from Georgia Tech with an MS and PhD in Mechanical Engineering and from Penn State with a BS in Mechanical Engineering.
"About the title" may belong to another edition of this title.
killarneybooks
Inagh, Clare, Ireland
AbeBooks seller since April 20, 2017
Shipping rates from Ireland to U.S.A.
| Item | 5 to 7 business days | 2 to 4 business days |
|---|---|---|
| First item | £ 29.84 | £ 32.54 |
Payment methods
- Bank Wire Transfer
- Paypal
Store description
All U.S.-bound orders are now shipped with UPS for reliable delivery. Additional customs or import fees are highly unlikely; however, please note buyers remain responsible for any duties or taxes that U.S. Customs may assess. -- Killarneybooks is a family-run bookshop based in the Republic of Ireland. We take pride in accurate listings, careful packaging, and prompt service - most orders ship within 24 hours. All books listed are in stock and ready for immediate dispatch - we are not dropshippers. Inquiries always welcome.…
Specialty
professional, academic, non-fictionSeller's business information
killarneybooks
Ireland
Terms of sale
Business Name: killarneybooks
Business Type: Sole Trader
Trade Register Number: 1976607T (not VAT-registered)
Business Address: Ballynoe, Inagh, Co. Clare
Customer Service representative: Ada Boosey
Phone: 00353 857512674
Email: killarneybookseu@yahoo.com
Right of withdrawal
If you are a consumer you can withdraw from the contract in accordance with the following. Consumer means any natural person who is acting for purposes which are outside his trade, business, craft or profession.
Information regarding the right of withdrawal
Statutory right to withdraw
You have the right to withdraw from this contract within 14 days without giving any reason.
The withdrawal period will expire after 14 days from the day on which you acquire, or a third party other than the carrier and indicated by you acquires, physical possession of the last good or the last lot or piece.
To exercise the right of withdrawal, electronically fill in and submit a clear statement on our website, under "My Purchases" in "My Account". We will communicate to you an acknowledgement of receipt of such a withdrawal on a durable medium (e.g. by e-mail) without delay.
To meet the withdrawal deadline, it is sufficient for you to send your communication concerning your exercise of the right of withdrawal before the withdrawal period has expired.
Effects of withdrawal
If you withdraw from this contract, we will reimburse to you all payments received from you, including the costs of delivery (except for the supplementary costs arising if you chose a type of delivery other than the least expensive type of standard delivery offered by us).
We may make a deduction from the reimbursement for loss in value of any goods supplied, if the loss is the result of unnecessary handling by you.
We will make the reimbursement without undue delay, and not later than 14 days after the day on which we are informed about your decision to withdraw from this contract.
We will make the reimbursement using the same means of payment as you used for the initial transaction, unless you have expressly agreed otherwise; in any event, you will not incur any fees as a result of such reimbursement.
We may withhold reimbursement until we have received the goods back, or you have supplied evidence of having sent back the goods, whichever is the earliest.
You shall send back the goods or hand them over to killarneybooks, Inagh, Clare, Ireland, without undue delay and in any event not later than 14 days from the day on which you communicate your withdrawal from this contract to us. The deadline is met if you send back the goods before the period of 14 days has expired. You will have to bear the direct cost of returning the goods. You are only liable for any diminished value of the goods resulting from the handling other than what is necessary to establish the nature, characteristics and functioning of the goods.
Exceptions to the right of withdrawal
The right of withdrawal does not apply to:
- The delivery of newspapers, journals or magazines with the exception of subscription contracts; and
- The supply of digital content which is not supplied on a tangible medium (e.g. on a CD or DVD) if you accepted when you placed your order that we could start to deliver it, and that you could not withdraw once delivery had started.
Shipping terms
TNT / FedEX express available on request. Please contact us for more details. Thank you.