Microbilles flottantes d'alginate de succinate de sumatriptan : Formulation, développement, évaluation
Language: French
Published by Editions Notre Savoir, 2026
- Softcover
- New
Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH
AbeBooks seller since August 14, 2006
Condition: New
£ 60.78
Quantity: 2 available
Add to basketItem description from seller
nach der Bestellung gedruckt Neuware - Printed after ordering - Le succinate de sumatriptan est efficace dans environ 70 % des crises de migraine, mais sa durée d'action est courte et sa biodisponibilité orale faible en raison du métabolisme de premier passage. Il présente une demi-vie d'élimination de 2,5 heures et est absorbé au niveau de l'estomac et de la partie supérieure de l'intestin grêle. Dans la présente étude, un système de microbilles flottantes d'alginate a été conçu pour favoriser la rétention gastrique. L'alginate de sodium (à faible teneur en méthoxy), l'HPMC K15M et le Pluronic F127 ont été sélectionnés pour la préparation des microbilles de succinate de sumatriptan. Les microbilles chargées en succinate de sumatriptan ont été préparées à l'aide de la méthode de gélification ionotrophique. L'effet de diverses variables de procédé, telles que la vitesse d'agitation, la taille de l'aiguille, la distance de dépose, le milieu de gélification et le temps de gélification, ainsi que des variables de formulation, a été étudié. Les microbilles préparées ont été évaluées en fonction de leurs propriétés micrométriques, du rendement en microbilles, du pourcentage de flottabilité, du pourcentage d'efficacité d'encapsulation du principe actif et du pourcentage de libération du principe actif. Dans le présent ouvrage, l'optimisation des variables de procédé et de formulation des microbilles a été réalisée. Cet ouvrage sera utile aux chercheurs travaillant dans le domaine du développement de formulations pharmaceutiques. …
Seller Inventory # 9786630328899
- Title
- Microbilles flottantes d'alginate de succinate de sumatriptan : Formulation, développement, évaluation
- Author
- Satej Patil
- Publisher
- Editions Notre Savoir
- Publication year
- 2026
- Condition
- Neu
- Binding
- Taschenbuch
- Language
- French
- ISBN 10
- 6630328892
- ISBN 13
- 9786630328899
- Item weight
- 191 grams
- Dimensions
- 220x150x7 mm
"Synopsis" may belong to another edition of this title.
Shipping rates from Germany to U.S.A.
| Item | 7 to 10 business days | 5 to 7 business days |
|---|---|---|
| First item | £ 30.03 | £ 38.61 |
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represented by the managing director Christel Glass
Garlebsen 48
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