Microarrays for the Neurosciences: An Essential Guide (Cellular and Molecular Neuroscience) (Cellular and Molecular Neuroscience Series)

ISBN 10: 0262072297 / ISBN 13: 9780262072298

Published by Bradford Books, 2002

May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend Less 1.85. Seller Inventory # G0262072297I4N00

Synopsis:

A guide to the use of DNA microarray technology in studying the central nervous system and other complex biological systems.The effort to sequence the human genome has generated a new discipline, functional genomics, or the study of the relationship between the genetic code and its biologic potential. Gene expression studies are made possible not only by the decoding of the human genome, but by the development of new technologies. The preeminent technology in this area, DNA microarrays, is helping to revolutionize the field of neuroscience. Rather than looking at one gene at a time, researchers using DNA microarrays can monitor the expression patterns of large numbers of genes simultaneously. Bridging the traditional gap between molecular neurobiology and systems neurobiology, DNA microarray technology has the potential to elevate molecular genetic studies of the nervous system to the system level. This book provides a comprehensive guide to the use of DNA microarrays in neuroscience and provides approaches that are applicable to other complex biological systems. Human nervous system tissue is remarkably complex. The number of cell types, the architecture, the developmental program, and the importance of environmental factors in development and functioning all pose particular challenges to the researcher using gene expression studies. After an overview of the technology, the book discusses array scanning and image application, statistical methods for array analysis, specific applications of gene expression studies in the central nervous system, the use of postmortem human tissue, and novel methods for using microarray data to develop hypotheses about regulatory networks.

About the Authors:

Daniel H. Geschwind is Assistant Professor of Neurology and Director of the Neurogenetics Program at the University of California at Los Angeles School of Medicine.

Jeffrey P. Gregg is Assistant Professor of Pathology and Director of Molecular Pathology at the University of California at Davis School of Medicine.

Bibliographic Details

Title: Microarrays for the Neurosciences: An ...
Publisher: Bradford Books
Publication Date: 2002
Binding: Hardcover
Condition: Very Good
Dust Jacket Condition: No Jacket